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    Cbr3 carbonyl reductase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304078, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cbr3provided by RGD
    Official Full Name
    carbonyl reductase 3provided by RGD
    Primary source
    RGD:1309728
    See related
    EnsemblRapid:ENSRNOG00000001701 AllianceGenome:RGD:1309728
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables 3-keto sterol reductase activity and carbonyl reductase (NADPH) activity. Involved in phylloquinone catabolic process. Predicted to be located in cytosol and nucleoplasm. Orthologous to human CBR3 (carbonyl reductase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 76.1), Lung (RPKM 47.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cbr3 in Genome Data Viewer
    Location:
    11q11
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (46478295..46486555)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (33008615..33016877)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (33909417..33917674)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene TruB pseudouridine synthase family member 2, pseudogene 6 Neighboring gene carbonyl reductase 1 like 3 Neighboring gene DOP1 leucine zipper like protein B Neighboring gene interferon induced transmembrane protein3, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Hippocampal protein expression is differentially affected by chronic paroxetine treatment in adolescent and adult rats: a possible mechanism of "paradoxical" antidepressant responses in young persons. Karanges EA, et al. Front Pharmacol, 2013. PMID 23847536, Free PMC Article
    2. Carbonyl Reductase 3 (CBR3) Mediates 9-cis-Retinoic Acid-Induced Cytostatis and is a Potential Prognostic Marker for Oral Malignancy. Ohkura-Hada S, et al. Open Dent J, 2008. PMID 19088887, Free PMC Article
    3. Investigation of the role of the amino acid residue at position 230 for catalysis in monomeric carbonyl reductase 3. Miura T, et al. Chem Biol Interact, 2009 Mar 16. PMID 18983987
    4. Different functions between human monomeric carbonyl reductase 3 and carbonyl reductase 1. Miura T, et al. Mol Cell Biochem, 2008 Aug. PMID 18493841
    5. New developments in anthracycline-induced cardiotoxicity. Mordente A, et al. Curr Med Chem, 2009. PMID 19442138

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3-keto sterol reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NADPH binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NADPH dehydrogenase (quinone) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NADPH dehydrogenase (quinone) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables carbonyl reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carbonyl reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables carbonyl reductase (NADPH) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cognition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phylloquinone catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    carbonyl reductase [NADPH] 3
    Names
    monomeric carbonyl reductase 3
    quinone reductase CBR3
    NP_001100580.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107110.1 → NP_001100580.1  carbonyl reductase [NADPH] 3

      See identical proteins and their annotated locations for NP_001100580.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474083
      UniProtKB/Swiss-Prot
      B2GV72
      Related
      ENSRNOP00000002310.4, ENSRNOT00000002310.8
      Conserved Domains (2) summary
      cd05324
      Location:6 → 277
      carb_red_PTCR-like_SDR_c; Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs
      pfam00106
      Location:6 → 241
      adh_short; short chain dehydrogenase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      46478295..46486555
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B2GV72.1 GenPept UniProtKB/Swiss-Prot:B2GV72

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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