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    Ncald neurocalcin delta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 553106, updated on 27-Nov-2024

    Summary

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    Symbol
    Ncaldprovided by RGD
    Full Name
    neurocalcin deltaprovided by RGD
    Primary source
    RGD:1560287
    See related
    EnsemblRapid:ENSRNOG00000042978 AllianceGenome:RGD:1560287
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables actin binding activity and alpha-tubulin binding activity. Predicted to be involved in calcium-mediated signaling and regulation of signal transduction. Predicted to act upstream of or within regulation of systemic arterial blood pressure. Orthologous to human NCALD (neurocalcin delta). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 712.8), Lung (RPKM 121.1) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ncald in Genome Data Viewer
    Location:
    7q22
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (70417683..70849763, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (68532671..68964740, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (76199305..76632847, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene ferritin light chain 1, pseudogene 7 Neighboring gene grainyhead-like transcription factor 2 Neighboring gene nucleus accumbens associated 1, pseudogene 1 Neighboring gene 60S ribosomal protein L29-like Neighboring gene uncharacterized LOC120093633 Neighboring gene uncharacterized LOC134479713 Neighboring gene uncharacterized LOC120093634 Neighboring gene ribonucleotide reductase regulatory TP53 inducible subunit M2B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Ca(2+) modulation of ANF-RGC: new signaling paradigm interlocked with blood pressure regulation. Duda T, et al. Biochemistry, 2012 Nov 20. PMID 23088492, Free PMC Article
    2. ONE-GC membrane guanylate cyclase, a trimodal odorant signal transducer. Duda T, et al. Biochem Biophys Res Commun, 2008 Mar 7. PMID 18178149
    3. Identification of Ca2+-dependent binding partners for the neuronal calcium sensor protein neurocalcin delta: interaction with actin, clathrin and tubulin. Ivings L, et al. Biochem J, 2002 May 1. PMID 11964161, Free PMC Article
    4. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
    5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables alpha-tubulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables clathrin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tubulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of systemic arterial blood pressure ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    neurocalcin-delta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024371.1 → NP_001019542.1  neurocalcin-delta

      See identical proteins and their annotated locations for NP_001019542.1

      Status: PROVISIONAL

      Source sequence(s)
      BC087105
      UniProtKB/Swiss-Prot
      Q5PQN0
      UniProtKB/TrEMBL
      A6HR47
      Conserved Domains (1) summary
      COG5126
      Location:14 → 179
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      70417683..70849763 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008765456.3 → XP_008763678.1  neurocalcin-delta isoform X1

      See identical proteins and their annotated locations for XP_008763678.1

      UniProtKB/Swiss-Prot
      Q5PQN0
      UniProtKB/TrEMBL
      A6HR47
      Conserved Domains (1) summary
      COG5126
      Location:14 → 179
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    2. XM_063264158.1 → XP_063120228.1  neurocalcin-delta isoform X1

      UniProtKB/Swiss-Prot
      Q5PQN0
      UniProtKB/TrEMBL
      A6HR47

    3. XM_063264157.1 → XP_063120227.1  neurocalcin-delta isoform X1

      UniProtKB/Swiss-Prot
      Q5PQN0
      UniProtKB/TrEMBL
      A6HR47
      Related
      ENSRNOP00000073597.1, ENSRNOT00000080024.3

    4. XM_063264159.1 → XP_063120229.1  neurocalcin-delta isoform X1

      UniProtKB/Swiss-Prot
      Q5PQN0
      UniProtKB/TrEMBL
      A6HR47

    5. XM_063264160.1 → XP_063120230.1  neurocalcin-delta isoform X1

      UniProtKB/Swiss-Prot
      Q5PQN0
      UniProtKB/TrEMBL
      A6HR47

    6. XM_039079786.2 → XP_038935714.1  neurocalcin-delta isoform X1

      UniProtKB/Swiss-Prot
      Q5PQN0
      UniProtKB/TrEMBL
      A6HR47
      Conserved Domains (1) summary
      COG5126
      Location:14 → 179
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    7. XM_039079787.2 → XP_038935715.1  neurocalcin-delta isoform X1

      UniProtKB/Swiss-Prot
      Q5PQN0
      UniProtKB/TrEMBL
      A6HR47
      Conserved Domains (1) summary
      COG5126
      Location:14 → 179
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    8. XM_017595065.3 → XP_017450554.1  neurocalcin-delta isoform X1

      UniProtKB/Swiss-Prot
      Q5PQN0
      UniProtKB/TrEMBL
      A6HR47
      Conserved Domains (1) summary
      COG5126
      Location:14 → 179
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    9. XM_063264162.1 → XP_063120232.1  neurocalcin-delta isoform X1

      UniProtKB/Swiss-Prot
      Q5PQN0
      UniProtKB/TrEMBL
      A6HR47

    RNA

    1. XR_010053035.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5PQN0.3 GenPept UniProtKB/Swiss-Prot:Q5PQN0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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