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    Mrpl14 mitochondrial ribosomal protein L14 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301250, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mrpl14provided by RGD
    Official Full Name
    mitochondrial ribosomal protein L14provided by RGD
    Primary source
    RGD:1306240
    See related
    EnsemblRapid:ENSRNOG00000019734 AllianceGenome:RGD:1306240
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    L14mt; L32mt; MRP-L14; MRP-L32
    Summary
    Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in ribosome. Predicted to be part of mitochondrial large ribosomal subunit. Predicted to be active in mitochondrion. Orthologous to human MRPL14 (mitochondrial ribosomal protein L14). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 178.5), Heart (RPKM 168.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mrpl14 in Genome Data Viewer
    Location:
    9q12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (22800286..22812711, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (15302840..15315195, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (17687622..17698591, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102550363 Neighboring gene uncharacterized LOC103690501 Neighboring gene transmembrane protein 63B Neighboring gene calpain 11 Neighboring gene myomixer, myoblast fusion factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mammalian mitochondrial ribosomal proteins. N-terminal amino acid sequencing, characterization, and identification of corresponding gene sequences. Goldschmidt-Reisin S, et al. J Biol Chem, 1998 Dec 25. PMID 9857009
    2. Structures of the human mitochondrial ribosome in native states of assembly. Brown A, et al. Nat Struct Mol Biol, 2017 Oct. PMID 28892042, Free PMC Article
    3. Structure of the large ribosomal subunit from human mitochondria. Brown A, et al. Science, 2014 Nov 7. PMID 25278503, Free PMC Article
    4. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
    5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of mitochondrial large ribosomal subunit IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mitochondrial large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial large ribosomal subunit ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    large ribosomal subunit protein uL14m
    Names
    39S ribosomal protein L14, mitochondrial
    39S ribosomal protein L32, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106890.2 → NP_001100360.1  large ribosomal subunit protein uL14m precursor

      See identical proteins and their annotated locations for NP_001100360.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      Q7M0E7
      UniProtKB/TrEMBL
      A0A8L2QE87, A6JIW8, A6JIW9
      Conserved Domains (1) summary
      cl00328
      Location:33 → 141
      Ribosomal_L14; Ribosomal protein L14p/L23e

    2. NM_001271131.1 → NP_001258060.1  large ribosomal subunit protein uL14m precursor

      See identical proteins and their annotated locations for NP_001258060.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      FM100935, JAXUCZ010000009
      UniProtKB/Swiss-Prot
      Q7M0E7
      UniProtKB/TrEMBL
      A0A8L2QE87, A6JIW8, A6JIW9
      Conserved Domains (1) summary
      cl00328
      Location:33 → 141
      Ribosomal_L14; Ribosomal protein L14p/L23e

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      22800286..22812711 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039083182.2 → XP_038939110.2  large ribosomal subunit protein uL14m isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZYP8
      Related
      ENSRNOP00000084197.1, ENSRNOT00000093810.2

    2. XM_039083181.2 → XP_038939109.1  large ribosomal subunit protein uL14m isoform X1

      UniProtKB/Swiss-Prot
      Q7M0E7
      UniProtKB/TrEMBL
      A0A8L2QE87, A6JIW8, A6JIW9
      Conserved Domains (1) summary
      cl00328
      Location:33 → 141
      Ribosomal_L14; Ribosomal protein L14p/L23e

    3. XM_008766850.4 → XP_008765072.1  large ribosomal subunit protein uL14m isoform X1

      See identical proteins and their annotated locations for XP_008765072.1

      UniProtKB/Swiss-Prot
      Q7M0E7
      UniProtKB/TrEMBL
      A0A8L2QE87, A6JIW8, A6JIW9
      Conserved Domains (1) summary
      cl00328
      Location:33 → 141
      Ribosomal_L14; Ribosomal protein L14p/L23e

    4. XM_006244512.5 → XP_006244574.1  large ribosomal subunit protein uL14m isoform X1

      See identical proteins and their annotated locations for XP_006244574.1

      UniProtKB/Swiss-Prot
      Q7M0E7
      UniProtKB/TrEMBL
      A0A8L2QE87, A6JIW8, A6JIW9
      Conserved Domains (1) summary
      cl00328
      Location:33 → 141
      Ribosomal_L14; Ribosomal protein L14p/L23e
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7M0E7.2 GenPept UniProtKB/Swiss-Prot:Q7M0E7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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