Svbp small vasohibin binding protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Svbpprovided by RGD
Official Full Name: small vasohibin binding proteinprovided by RGD
Primary source: RGD:1311232
See related: EnsemblRapid:ENSRNOG00000007404 AllianceGenome:RGD:1311232
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ccdc23; RGD1311232
Summary: Predicted to enable microtubule binding activity and peptidase activator activity. Predicted to be involved in several processes, including nervous system development; protein secretion; and regulation of protein metabolic process. Predicted to act upstream of or within negative regulation of endothelial cell migration. Predicted to be located in cytoplasm; cytoskeleton; and extracellular region. Predicted to be active in apical part of cell. Orthologous to human SVBP (small vasohibin binding protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 193.8), Adrenal (RPKM 90.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (138091773..138099048)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (132808021..132813735)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (138245639..138251353)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knocking down Svbp in rat primary hippocampal neurons led to a significant decrease in the number of excitatory synapses. SVBP is not only involved in angiogenesis, but also has vital functions in the central nervous system. Biallelic loss-of-function variants in SVBP lead to intellectual disability.
Title: Loss of function of SVBP leads to autosomal recessive intellectual disability, microcephaly, ataxia, and hypotonia.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	ISS Inferred from Sequence or Structural Similarity more info
enables peptidase activator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in axon development	ISO Inferred from Sequence Orthology more info
involved_in axon development	ISS Inferred from Sequence or Structural Similarity more info
involved_in brain development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein secretion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein secretion	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of metallopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of metallopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in apical part of cell	IBA Inferred from Biological aspect of Ancestor more info
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: small vasohibin-binding protein

Names: coiled-coil domain containing 23; coiled-coil domain-containing protein 23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.