Isyna1 inositol-3-phosphate synthase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Isyna1provided by RGD
Official Full Name: inositol-3-phosphate synthase 1provided by RGD
Primary source: RGD:1359423
See related: EnsemblRapid:ENSRNOG00000019741 AllianceGenome:RGD:1359423
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables inositol-3-phosphate synthase activity. Involved in inositol biosynthetic process and negative regulation of inositol biosynthetic process. Predicted to be active in cytoplasm. Orthologous to human ISYNA1 (inositol-3-phosphate synthase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Testes (RPKM 150.3), Adrenal (RPKM 115.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16p14

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (18873119..18876116, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (18839143..18841979, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (20589497..20592333, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Differential phosphorylation of IPS isoforms in brain, intestine and testis suggests novel functions in these tissues.
Title: Rat brain myo-inositol 3-phosphate synthase is a phosphoprotein.
Isyna1 is regulated, in part, by DNA methylation and that significant alterations in methylation patterns during development could have a major impact on inositol phosphate synthase expression in later life.
Title: Differential methylation of the gene encoding myo-inositol 3-phosphate synthase (Isyna1) in rat tissues.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:498303 (e-PCR)
- UniSTS:498303

Isyna1 (e-PCR), detects polymorphism
- UniSTS:498303

RH130875 (e-PCR)
- UniSTS:214159

RH136677 (e-PCR)
- UniSTS:214159

RH129421 (e-PCR)
- UniSTS:212728

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
NOT enables inositol-3-phosphate synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables inositol-3-phosphate synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables inositol-3-phosphate synthase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in inositol biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in inositol biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in inositol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in inositol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inositol biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phospholipid biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: inositol-3-phosphate synthase 1

Names: IPS 1; MI-1-P synthase; MIP synthase; myo-inositol 1-phosphate synthase A1; myo-inositol-1-phosphate synthase

NP_001013902.2

EC 5.5.1.4

XP_063131231.1

EC 5.5.1.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.