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    Scaper S-phase cyclin A-associated protein in the ER [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117521, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Scaperprovided by RGD
    Official Full Name
    S-phase cyclin A-associated protein in the ERprovided by RGD
    Primary source
    RGD:621585
    See related
    EnsemblRapid:ENSRNOG00000006864 AllianceGenome:RGD:621585
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Zfp291; Znf291
    Summary
    Predicted to enable nucleic acid binding activity and zinc ion binding activity. Predicted to act upstream of or within gonad development; retina development in camera-type eye; and spermatogenesis. Predicted to be located in several cellular components, including nuclear speck; ooplasm; and sperm head. Orthologous to human SCAPER (S-phase cyclin A associated protein in the ER). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 109.4), Heart (RPKM 86.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Scaper in Genome Data Viewer
    Location:
    8q24
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (64828789..65228240, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (55932717..56332222, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (60127039..60593568, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene bolA family member 2, pseudogene 1 Neighboring gene ISL LIM homeobox 2 Neighboring gene RNA-binding protein EWS-like Neighboring gene caspase-3-like Neighboring gene ubiquitin-conjugating enzyme E2 J2-like Neighboring gene kinesin-like protein KIF23 Neighboring gene sodium/potassium-transporting ATPase subunit beta-3-like Neighboring gene similar to PGC7 Neighboring gene developmental pluripotency associated 3-like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1454

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within antral ovarian follicle growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within ovarian follicle development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within retina development in camera-type eye ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within seminiferous tubule development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ooplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm head ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    S phase cyclin A-associated protein in the endoplasmic reticulum
    Names
    KIAA1454-like protein
    zinc finger protein 291

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427719.1 → NP_001414648.1  S phase cyclin A-associated protein in the endoplasmic reticulum

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      Related
      ENSRNOP00000110812.1, ENSRNOT00000171938.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      64828789..65228240 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008766363.4 → XP_008764585.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform X2

      See identical proteins and their annotated locations for XP_008764585.1

      UniProtKB/TrEMBL
      A6J4P9, F1LRM0
      Conserved Domains (6) summary
      smart00451
      Location:793 → 825
      ZnF_U1; U1-like zinc finger
      pfam09731
      Location:336 → 703
      Mitofilin; Mitochondrial inner membrane protein
      pfam16501
      Location:88 → 183
      SCAPER_N; S phase cyclin A-associated protein in the endoplasmic reticulum
      cd16269
      Location:763 → 773
      GBP_C; coiled coil [structural motif]
      cl02488
      Location:540 → 711
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl20817
      Location:669 → 777
      GBP_C; Guanylate-binding protein, C-terminal domain

    2. XM_039082386.2 → XP_038938314.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform X3

      UniProtKB/TrEMBL
      A6J4P9
      Conserved Domains (2) summary
      PTZ00121
      Location:532 → 918
      PTZ00121; MAEBL; Provisional
      pfam16501
      Location:94 → 191
      SCAPER_N; S phase cyclin A-associated protein in the endoplasmic reticulum

    3. XM_039082383.2 → XP_038938311.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform X1

      UniProtKB/TrEMBL
      A6J4P9
      Conserved Domains (2) summary
      PTZ00121
      Location:538 → 924
      PTZ00121; MAEBL; Provisional
      pfam16501
      Location:94 → 191
      SCAPER_N; S phase cyclin A-associated protein in the endoplasmic reticulum

    4. XM_039082384.2 → XP_038938312.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform X1

      UniProtKB/TrEMBL
      A6J4P9
      Conserved Domains (2) summary
      PTZ00121
      Location:538 → 924
      PTZ00121; MAEBL; Provisional
      pfam16501
      Location:94 → 191
      SCAPER_N; S phase cyclin A-associated protein in the endoplasmic reticulum

    5. XM_063264794.1 → XP_063120864.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform X2

      UniProtKB/TrEMBL
      F1LRM0

    6. XM_063264793.1 → XP_063120863.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform X1

    7. XM_039082388.2 → XP_038938316.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform X6

    8. XM_039082391.2 → XP_038938319.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform X8

    9. XM_063264796.1 → XP_063120866.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform X7

    10. XM_039082387.2 → XP_038938315.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform X4

      Conserved Domains (2) summary
      PTZ00121
      Location:538 → 924
      PTZ00121; MAEBL; Provisional
      pfam16501
      Location:94 → 191
      SCAPER_N; S phase cyclin A-associated protein in the endoplasmic reticulum

    11. XM_063264795.1 → XP_063120865.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version

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