Maoa monoamine oxidase A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Maoaprovided by RGD
Official Full Name: monoamine oxidase Aprovided by RGD
Primary source: RGD:61898
See related: AllianceGenome:RGD:61898
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mao
Summary: Enables heterocyclic compound binding activity and oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor. Involved in phenylethylamine metabolic process and serotonin metabolic process. Located in mitochondrial outer membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease; Brunner Syndrome; alcohol use disorder; autism spectrum disorder; and panic disorder. Orthologous to human MAOA (monoamine oxidase A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 1152.5), Liver (RPKM 471.7) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq11

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (8615239..8681372, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (6032172..6098308, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (6554698..6620722, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Monoamine oxidase is a source of cardiac oxidative stress in obese rats: the beneficial role of metformin.
Title: Monoamine oxidase is a source of cardiac oxidative stress in obese rats: the beneficial role of metformin.
The Link between Activities of Hepatic 11beta-Hydroxysteroid Dehydrogenase-1 and Monoamine Oxidase-A in the Brain Following Repeated Predator Stress: Focus on Heightened Anxiety.
Title: The Link between Activities of Hepatic 11beta-Hydroxysteroid Dehydrogenase-1 and Monoamine Oxidase-A in the Brain Following Repeated Predator Stress: Focus on Heightened Anxiety.
Redefining differential roles of MAO-A in dopamine degradation and MAO-B in tonic GABA synthesis.
Title: Redefining differential roles of MAO-A in dopamine degradation and MAO-B in tonic GABA synthesis.
Increased MAO-A Activity Promotes Progression of Pulmonary Arterial Hypertension.
Title: Increased MAO-A Activity Promotes Progression of Pulmonary Arterial Hypertension.
MAO-A is induced in diabetic aortas and vitamin D can improve diabetes-induced endothelial dysfunction by modulating the MAO-A expression.
Title: Vitamin D improves vascular function and decreases monoamine oxidase A expression in experimental diabetes.
Acute alcohol withdrawal was associated with elevated MAO-A levels and activity in the brain.
Title: Elevated monoamine oxidase A activity and protein levels in rodent brain during acute withdrawal after chronic intermittent ethanol vapor exposure.
These results suggest that the inhibition of Sirt1/MAO-A expression in astrocytes in the prefrontal cortex may contribute to the different anti-depressive effects of Repetitive transcranial magnetic stimulation with different parameters, and may also provide a novel insight into the mechanisms underlying major depressive disorder.
Title: Repetitive transcranial magnetic stimulation inhibits Sirt1/MAO-A signaling in the prefrontal cortex in a rat model of depression and cortex-derived astrocytes.
Extensive SAR studies and in vivo behavioral evaluations of this and other related analogue series identified a number of potential clinical development candidates; ultimately, compound 8f was identified as a candidate molecule with high selectivity toward MAO-B (29-56 nM) over MAO-A (19% inhibition at a screening concentration of 50 muM), an excellent profile against a panel of other enzymes and receptors, good pharma...
Title: Identification of 5-(1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)thiophene-2-Carboxamides as Novel and Selective Monoamine Oxidase B Inhibitors Used to Improve Memory and Cognition.
Amine oxidases are important mediators of pathological processes of rhabdomyolysis in rats.
Title: Amine oxidases as important agents of pathological processes of rhabdomyolysis in rats.
Consequently, MAO activities in a brain and a liver depend on the microsomal oxidation process.
Title: The role of microsomal oxidation in the regulation of monoamine oxidase activity in the brain and liver of rats.

Submit: New GeneRIF Correction See all GeneRIFs (33)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MAOA (e-PCR), detects polymorphism
- UniSTS:266903

AU028177 (e-PCR)
- UniSTS:112582

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables aliphatic amine oxidase activity	IEA Inferred from Electronic Annotation more info
enables flavin adenine dinucleotide binding	IBA Inferred from Biological aspect of Ancestor more info
enables flavin adenine dinucleotide binding	IDA Inferred from Direct Assay more info	PubMed
enables flavin adenine dinucleotide binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables monoamine oxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables monoamine oxidase activity	ISO Inferred from Sequence Orthology more info
enables primary methylamine oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables primary methylamine oxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables primary methylamine oxidase activity	IEA Inferred from Electronic Annotation more info
enables primary methylamine oxidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables primary methylamine oxidase activity	ISO Inferred from Sequence Orthology more info
enables serotonin binding	IDA Inferred from Direct Assay more info	PubMed
enables serotonin binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in catecholamine catabolic process	NAS Non-traceable Author Statement more info	PubMed
involved_in catecholamine metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within dopamine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in phenylethylamine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phenylethylamine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of signal transduction	ISO Inferred from Sequence Orthology more info
involved_in serotonin metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in serotonin metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: amine oxidase [flavin-containing] A

Names: MAO-A; monoamine oxidase type A

NP_387502.1

EC 1.4.3.21

EC 1.4.3.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.