Steap3 STEAP3 metalloreductase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Steap3provided by RGD
Official Full Name: STEAP3 metalloreductaseprovided by RGD
Primary source: RGD:708552
See related: EnsemblRapid:ENSRNOG00000049471 AllianceGenome:RGD:708552
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including FAD binding activity; heme binding activity; and oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor. Involved in positive regulation of apoptotic process. Predicted to be located in endosome membrane and multivesicular body. Predicted to be active in endosome and plasma membrane. Orthologous to human STEAP3 (STEAP3 metalloreductase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 117.9), Muscle (RPKM 98.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q11

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (33904710..33950100, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (31351954..31397344, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (36257220..36274144, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Research of STEAP3 interaction with Rab7A and RACK1 to modulate the MAPK and JAK/STAT signaling in Osteoarthritis.
Title: Research of STEAP3 interaction with Rab7A and RACK1 to modulate the MAPK and JAK/STAT signaling in Osteoarthritis.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables FAD binding	IEA Inferred from Electronic Annotation more info
enables FAD binding	ISO Inferred from Sequence Orthology more info
enables FAD binding	ISS Inferred from Sequence or Structural Similarity more info
enables cupric reductase (NADH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables cupric reductase (NADH) activity	ISO Inferred from Sequence Orthology more info
enables ferric-chelate reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables ferric-chelate reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info
enables ferric-chelate reductase (NADPH) activity	ISO Inferred from Sequence Orthology more info
enables ferric-chelate reductase (NADPH) activity	ISS Inferred from Sequence or Structural Similarity more info
enables ferric-chelate reductase activity	ISO Inferred from Sequence Orthology more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables heme binding	ISO Inferred from Sequence Orthology more info
enables heme binding	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in copper ion import	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within copper ion import	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within exosomal secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within iron import into cell	ISO Inferred from Sequence Orthology more info
involved_in iron ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within iron ion transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in protein secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein secretion	ISO Inferred from Sequence Orthology more info
involved_in protein secretion	ISO Inferred from Sequence Orthology more info
involved_in protein secretion	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
located_in endosome membrane	ISO Inferred from Sequence Orthology more info
located_in endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in multivesicular body	IEA Inferred from Electronic Annotation more info
located_in multivesicular body	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: metalloreductase STEAP3

Names: STEAP family member 3, metalloreductase; pHyde; six-transmembrane epithelial antigen of prostate 3; tumor suppressor pHyde

NP_579848.2

EC 1.16.1.-

XP_038946222.1

EC 1.16.1.-

XP_038946223.1

EC 1.16.1.-

XP_038946224.1

EC 1.16.1.-

XP_063128054.1

EC 1.16.1.-

XP_063128055.1

EC 1.16.1.-

XP_063128056.1

EC 1.16.1.-

XP_063128057.1

EC 1.16.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133314.2 → NP_579848.2 metalloreductase STEAP3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

Q5RKL5, Q99P41

UniProtKB/TrEMBL

A6K7Z6

Related

ENSRNOP00000095399.2, ENSRNOT00000101486.2

Conserved Domains (2) summary

COG2085
Location:29 → 209

COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]

pfam01794
Location:262 → 405

Ferric_reduct; Ferric reductase like transmembrane component

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

33904710..33950100 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039090296.1 → XP_038946224.1 metalloreductase STEAP3 isoform X5

Conserved Domains (2) summary

COG2085
Location:67 → 247

COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]

pfam01794
Location:300 → 388

Ferric_reduct; Ferric reductase like transmembrane component
XM_039090294.1 → XP_038946222.1 metalloreductase STEAP3 isoform X1

UniProtKB/TrEMBL

A0A8I6AMK0

Related

ENSRNOP00000105584.1, ENSRNOT00000123261.1

Conserved Domains (2) summary

COG2085
Location:67 → 247

COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]

pfam01794
Location:300 → 443

Ferric_reduct; Ferric reductase like transmembrane component
XM_063271985.1 → XP_063128055.1 metalloreductase STEAP3 isoform X4

UniProtKB/Swiss-Prot

Q5RKL5, Q99P41

UniProtKB/TrEMBL

A6K7Z6

Related

ENSRNOP00000086517.2, ENSRNOT00000104769.2
XM_063271987.1 → XP_063128057.1 metalloreductase STEAP3 isoform X7
XM_039090295.2 → XP_038946223.1 metalloreductase STEAP3 isoform X2

UniProtKB/TrEMBL

A0A8I6AGN2

Related

ENSRNOP00000092490.1, ENSRNOT00000106336.2

Conserved Domains (2) summary

COG2085
Location:39 → 219

COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]

pfam01794
Location:272 → 415

Ferric_reduct; Ferric reductase like transmembrane component
XM_063271986.1 → XP_063128056.1 metalloreductase STEAP3 isoform X6
XM_063271984.1 → XP_063128054.1 metalloreductase STEAP3 isoform X3

UniProtKB/TrEMBL

A0A0H2UI26

Related

ENSRNOP00000064137.3, ENSRNOT00000071388.4