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    Trh thyrotropin releasing hormone [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25569, updated on 27-Nov-2024

    Summary

    Official Symbol
    Trhprovided by RGD
    Official Full Name
    thyrotropin releasing hormoneprovided by RGD
    Primary source
    RGD:3903
    See related
    EnsemblRapid:ENSRNOG00000011824 AllianceGenome:RGD:3903
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    THR; Trf; TRH01; Pro-TRH
    Summary
    This gene encodes a member of the thyrotropin-releasing hormone family. Cleavage of the encoded proprotein releases mature thyrotropin-releasing hormone, which is a tripeptide hypothalamic regulatory hormone. The rat proprotein contains five thyrotropin-releasing hormone tripeptides. Thyrotropin-releasing hormone is involved in the regulation and release of thyroid-stimulating hormone, as well as prolactin, and may be involved in cardiac function in heart failure. Disruption of this gene is associated with hypothyroidism, elevated thyroid-stimulating hormone levels, and hyperglycemia. [provided by RefSeq, May 2013]
    Expression
    Biased expression in Brain (RPKM 29.7), Testes (RPKM 9.2) and 3 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Trh in Genome Data Viewer
    Location:
    4q34
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (126299236..126301762, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (124742111..124777094, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (124110716..124113242, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103692187 Neighboring gene mitochondrial ribosomal protein S25 Neighboring gene uncharacterized LOC134486818 Neighboring gene rabenosyn, RAB effector Neighboring gene prickle planar cell polarity protein 2 Neighboring gene uncharacterized LOC134486613 Neighboring gene uncharacterized LOC134486616

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables thyrotropin-releasing hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables thyrotropin-releasing hormone activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within adult walking behavior ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in eating behavior IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in eating behavior IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in histamine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in histamine metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in hormone-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of feeding behavior IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of glutamate secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of glutamate secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of gamma-aminobutyric acid secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of gamma-aminobutyric acid secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of insulin secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of insulin secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to corticosterone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to ethanol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to glucose IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in secretory granule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in secretory granule IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    thyrotropin releasing hormone
    Names
    TSH-releasing factor
    pro-thyrotropin-releasing hormone
    prothyroliberin
    protirelin
    thyrotropin-releasing factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013046.3NP_037178.1  thyrotropin releasing hormone preproprotein

      See identical proteins and their annotated locations for NP_037178.1

      Status: REVIEWED

      Source sequence(s)
      FQ100942, FQ221609, FQ223091
      UniProtKB/Swiss-Prot
      P01150
      UniProtKB/TrEMBL
      B1WBP2
      Related
      ENSRNOP00000015944.2, ENSRNOT00000015944.7
      Conserved Domains (1) summary
      pfam05438
      Location:6222
      TRH; Thyrotropin-releasing hormone (TRH)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      126299236..126301762 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)