Lrat lecithin retinol acyltransferase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lratprovided by RGD
Official Full Name: lecithin retinol acyltransferaseprovided by RGD
Primary source: RGD:68362
See related: EnsemblRapid:ENSRNOG00000025608 AllianceGenome:RGD:68362
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables phosphatidylcholine-retinol O-acyltransferase activity; retinoic acid binding activity; and retinol binding activity. Involved in response to retinoic acid; response to vitamin A; and retinol metabolic process. Located in multivesicular body; perinuclear region of cytoplasm; and rough endoplasmic reticulum. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 14 and retinitis pigmentosa. Orthologous to human LRAT (lecithin retinol acyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 191.9), Liver (RPKM 153.0) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (170562148..170571212, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (168264093..168273155, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (181896304..181905366, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Lrat(-/-) Rat: CRISPR/Cas9 Construction and Phenotyping of a New Animal Model for Retinitis Pigmentosa.
Title: The Lrat(-/-) Rat: CRISPR/Cas9 Construction and Phenotyping of a New Animal Model for Retinitis Pigmentosa.
In obese and dyslipidemic fa/fa rats, intestinal beta-Carotene 15,15'-Monooxygenase gene expression was increased, whereas hepatic lecithin:retinol acyltransferase gene expression was deceased.
Title: Altered expression of both β-carotene 15,15' monooxygenase and lecithin:retinol acyltransferase in obese Zucker rats.
proximal region together with basal transcription factors may be sufficient to drive Lrat expression.
Title: An essential set of basic DNA response elements is required for receptor-dependent transcription of the lecithin:retinol acyltransferase (Lrat) gene.
The results show that the major 5.3 kb transcript uses the canonical signal AAUAAA located at nt 5308, and the major short transcript of approximately 1.5 kb uses the non-canonical signal AUUAAA located at nt 1330.
Title: Cloning and molecular expression analysis of large and small lecithin:retinol acyltransferase mRNAs in the liver and other tissues of adult rats.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables O-acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylcholine-retinol O-acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylcholine-retinol O-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylcholine-retinol O-acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables retinoic acid binding	IDA Inferred from Direct Assay more info	PubMed
enables retinol binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of lipid transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in response to retinoic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to vitamin A	IEP Inferred from Expression Pattern more info	PubMed
involved_in retinol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in retinol metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in retinol metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within retinol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in retinol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in visual perception	IEA Inferred from Electronic Annotation more info
involved_in vitamin A metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within vitamin A metabolic process	ISO Inferred from Sequence Orthology more info
involved_in vitamin A metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in multivesicular body	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in rough endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in rough endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: lecithin retinol acyltransferase

Names: lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase); phosphatidylcholine--retinol O-acyltransferase

NP_071616.1

EC 2.3.1.135

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.