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    Gja5 gap junction protein, alpha 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 50563, updated on 3-Dec-2024

    Summary

    Official Symbol
    Gja5provided by RGD
    Official Full Name
    gap junction protein, alpha 5provided by RGD
    Primary source
    RGD:2692
    See related
    EnsemblRapid:ENSRNOG00000017484 AllianceGenome:RGD:2692
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cx40; Cxni
    Summary
    Enables connexin binding activity; disordered domain specific binding activity; and gap junction channel activity. Involved in several processes, including blood vessel diameter maintenance; cell communication by chemical coupling; and regulation of blood pressure. Located in cell projection. Part of connexin complex. Used to study hypertension. Biomarker of artery disease (multiple); glomerulonephritis; obesity; overactive bladder syndrome; and ureteral obstruction. Human ortholog(s) of this gene implicated in atrial fibrillation; atrial standstill 1; familial atrial fibrillation; and tetralogy of Fallot. Orthologous to human GJA5 (gap junction protein alpha 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 84.8), Heart (RPKM 24.7) and 6 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Gja5 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (187291227..187310770)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (184602407..184621952)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (199162745..199184942)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene gap junction protein, alpha 8 Neighboring gene Fcf1 rRNA-processing protein, pseudogene 4 Neighboring gene tubulin, alpha 1C, pseudogene 5 Neighboring gene uncharacterized LOC102553665

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within AV node cell to bundle of His cell communication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in AV node cell to bundle of His cell communication by electrical coupling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within SA node cell action potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in artery morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in atrial cardiac muscle cell to AV node cell communication by electrical coupling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in atrial cardiac muscle cell to AV node cell communication by electrical coupling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in atrial septum development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within atrial septum morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within atrial ventricular junction remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within blood vessel development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within blood vessel diameter maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in bundle of His cell to Purkinje myocyte communication by electrical coupling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cardiac conduction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cardiac conduction system development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell communication by chemical coupling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell communication by electrical coupling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cell communication by electrical coupling involved in cardiac conduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell communication by electrical coupling involved in cardiac conduction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell communication involved in cardiac conduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell-cell signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to platelet-derived growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within embryonic heart tube development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within embryonic limb morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endothelium development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within foramen ovale closure ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in gap junction assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in heart development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in heart development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in mitral valve development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of glomerular filtration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in outflow tract morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell communication by chemical coupling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of vasoconstriction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in potassium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in pulmonary valve formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of AV node cell action potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of Purkinje myocyte action potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of atrial cardiac muscle cell action potential ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of atrial cardiac muscle cell membrane depolarization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of atrial cardiac muscle cell membrane depolarization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of bundle of His cell action potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cardiac muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell communication by electrical coupling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of heart rate by cardiac conduction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of membrane depolarization during cardiac muscle cell action potential ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of renin secretion into blood stream ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of systemic arterial blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of regulation of ventricular cardiac muscle cell membrane depolarization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of ventricular cardiac muscle cell membrane depolarization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of regulation of ventricular cardiac muscle cell membrane repolarization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of ventricular cardiac muscle cell membrane repolarization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within renal system process involved in regulation of systemic arterial blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within septum primum development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within skeletal system development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vasodilation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vasomotion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within ventricular cardiac muscle cell action potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ventricular septum development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ventricular septum morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of connexin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of connexin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of connexin complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    part_of connexin complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in gap junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intercalated disc ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    gap junction alpha-5 protein
    Names
    connexin 40
    connexin i
    gap junction membrane channel protein alpha 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019280.1NP_062153.1  gap junction alpha-5 protein

      See identical proteins and their annotated locations for NP_062153.1

      Status: PROVISIONAL

      Source sequence(s)
      AF021806
      UniProtKB/Swiss-Prot
      P28234
      UniProtKB/TrEMBL
      A0A654ICD7, A6K3A5
      Related
      ENSRNOP00000076921.1, ENSRNOT00000108116.2
      Conserved Domains (2) summary
      pfam00029
      Location:3230
      Connexin
      pfam16791
      Location:255356
      Connexin40_C; Connexin 40 C-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      187291227..187310770
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063282415.1XP_063138485.1  gap junction alpha-5 protein isoform X1

      UniProtKB/Swiss-Prot
      P28234
      UniProtKB/TrEMBL
      A0A654ICD7, A6K3A5
      Related
      ENSRNOP00000080221.1, ENSRNOT00000115241.2