Gpr83 G protein-coupled receptor 83 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gpr83provided by RGD
Official Full Name: G protein-coupled receptor 83provided by RGD
Primary source: RGD:619891
See related: EnsemblRapid:ENSRNOG00000030318 AllianceGenome:RGD:619891
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gir
Summary: Predicted to enable neuropeptide receptor activity. Predicted to be involved in feeding behavior; neuropeptide signaling pathway; and phospholipase C-activating G protein-coupled receptor signaling pathway. Predicted to act upstream of or within response to glucocorticoid. Predicted to be located in non-motile cilium. Predicted to be active in plasma membrane. Orthologous to human GPR83 (G protein-coupled receptor 83). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 51.5), Brain (RPKM 23.9) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 8q12

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (19974995..19985483)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (11693540..11704028)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (13365583..13376071)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AI102409 (e-PCR)
- UniSTS:261131

RH137605 (e-PCR)
- UniSTS:219692

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables neuropeptide Y receptor activity	IEA Inferred from Electronic Annotation more info
enables neuropeptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in feeding behavior	IEA Inferred from Electronic Annotation more info
involved_in feeding behavior	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in neuropeptide signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in response to glucocorticoid	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to glucocorticoid	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cilium	ISO Inferred from Sequence Orthology more info
located_in non-motile cilium	IEA Inferred from Electronic Annotation more info
located_in non-motile cilium	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: G-protein coupled receptor 83

Names: glucocorticoid-induced receptor; probable G-protein coupled receptor 83

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_080411.2 → NP_536336.1 G-protein coupled receptor 83 precursor

See identical proteins and their annotated locations for NP_536336.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

Q8VHD7

UniProtKB/TrEMBL

A0A8I5ZSC1

Related

ENSRNOP00000043707.1, ENSRNOT00000044945.4

Conserved Domains (2) summary

pfam00001
Location:87 → 344

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:77 → 224

7tm_4; Olfactory receptor