Gpnmb glycoprotein nmb [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gpnmbprovided by RGD
Official Full Name: glycoprotein nmbprovided by RGD
Primary source: RGD:71008
See related: EnsemblRapid:ENSRNOG00000008816 AllianceGenome:RGD:71008
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable heparin binding activity; signaling receptor binding activity; and syndecan binding activity. Involved in bone mineralization and osteoblast differentiation. Predicted to be located in cytoplasmic vesicle and membrane. Predicted to be active in plasma membrane. Biomarker of brain infarction. Human ortholog(s) of this gene implicated in primary localized cutaneous amyloidosis 3. Orthologous to human GPNMB (glycoprotein nmb). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 680.2), Lung (RPKM 437.6) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q24

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (79341128..79362366)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (78010247..78031491)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (78694447..78715685)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Glycoprotein Non-metastatic Melanoma Protein B (GPNMB) Protects Against Neuroinflammation and Neuronal Loss in Pilocarpine-induced Epilepsy via the Regulation of Microglial Polarization.
Title: Glycoprotein Non-metastatic Melanoma Protein B (GPNMB) Protects Against Neuroinflammation and Neuronal Loss in Pilocarpine-induced Epilepsy via the Regulation of Microglial Polarization.
GPNMB Modulates Autophagy to Enhance Functional Recovery After Spinal Cord Injury in Rats.
Title: GPNMB Modulates Autophagy to Enhance Functional Recovery After Spinal Cord Injury in Rats.
Altered expression of glycoprotein nonmetastatic melanoma protein B in the distal sciatic nerve following injury.
Title: Altered expression of glycoprotein non‑metastatic melanoma protein B in the distal sciatic nerve following injury.
objective of this study is to investigate the potential regenerative effect of OA embedded and delivered via a cross-linked gelatin hydrogel within a volumetric tibialis anterior muscle defect in a rat model
Title: Exploratory study on the effect of osteoactivin on muscle regeneration in a rat volumetric muscle loss model.
This is the first experimental study to show that GPNMB adversely influences myocardial remodeling.
Title: Adverse left ventricular remodeling by glycoprotein nonmetastatic melanoma protein B in myocardial infarction.
A simultaneous increase in osteoactivin occurred with factors involved in tissue repair (MMPs and HSP72), in tissue regeneration after repetitive overuse.
Title: Growth and repair factors, osteoactivin, matrix metalloproteinase and heat shock protein 72, increase with resolution of inflammation in musculotendinous tissues in a rat model of repetitive grasping.
The GPNMB is a promising biomarker and therapeutic target for the development and progression of Nonalcoholic fatty liver disease in obesity.
Title: Beneficial impact of Gpnmb and its significance as a biomarker in nonalcoholic steatohepatitis.
Glycoprotein nonmetastatic melanoma protein B plays an important role in angiogenesis during hyperoxia injury
Title: Role of microRNA-150 and glycoprotein nonmetastatic melanoma protein B in angiogenesis during hyperoxia-induced neonatal lung injury.
translocalization of carboxy-terminal fragment of osteoactivin to the nucleus and the endoplasmic reticulum
Title: An intracellular fragment of osteoactivin formed by ectodomain shedding translocated to the nucleoplasm and bound to RNA binding proteins.
Osteoactivin is expressed in the kidney after acute cyclosporine A toxicity, and mainly expresses in the tubular epithelial cells and renal interstitium
Title: [Expression and mechanism of osteoactivin in the kidney of SD rats after acute cyclosporine A toxicity].

Submit: New GeneRIF Correction See all GeneRIFs (19)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info
enables syndecan binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in bone mineralization	IEP Inferred from Expression Pattern more info	PubMed
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-cell signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in osteoblast differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of tissue remodeling	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
located_in melanosome membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transmembrane glycoprotein NMB

Names: glycoprotein (transmembrane) nmb; osteoactivin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133298.1 → NP_579832.1 transmembrane glycoprotein NMB precursor

See identical proteins and their annotated locations for NP_579832.1

Status: PROVISIONAL

Source sequence(s)

AF184983

UniProtKB/Swiss-Prot

Q6P7C7

UniProtKB/TrEMBL

A6K0K2, Q9QZF6

Related

ENSRNOP00000076498.1, ENSRNOT00000104789.2

Conserved Domains (1) summary

cd00146
Location:263 → 316

PKD; polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is ...