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    CNGC11 cyclic nucleotide-gated channels [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819252, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CNGC11
    Official Full Name
    cyclic nucleotide-gated channels
    Primary source
    TAIR:AT2G46440
    Locus tag
    AT2G46440
    See related
    Araport:AT2G46440
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATCNGC11; cyclic nucleotide-gated channel 11; CYCLIC NUCLEOTIDE-GATED CHANNEL 11; cyclic nucleotide-gated channels; F11C10.13
    Summary
    Member of Cyclic nucleotide gated channel family. Positive regulator of resistance against avirulent fungal pathogen.
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    Genomic context

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    See CNGC11 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    7
    Sequence:
    Chromosome: 2; NC_003071.7 (19061688..19064937)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene helicase with zinc finger protein Neighboring gene cyclic nucleotide gated channel 3 Neighboring gene cyclic nucleotide-gated channel 12 Neighboring gene OxaA/YidC-like membrane insertion protein Neighboring gene Polynucleotidyl transferase, ribonuclease H-like superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. High throughput chemical screening supports the involvement of Ca2+ in cyclic nucleotide-gated ion channel-mediated programmed cell death in Arabidopsis. Abdel-Hamid H, et al. Plant Signal Behav, 2011 Nov. PMID 22041991, Free PMC Article
    2. The cyclic nucleotide-gated channels AtCNGC11 and 12 are involved in multiple Ca²⁺-dependent physiological responses and act in a synergistic manner. Urquhart W, et al. J Exp Bot, 2011 Jun. PMID 21414958, Free PMC Article
    3. Importance of the alphaC-helix in the cyclic nucleotide binding domain for the stable channel regulation and function of cyclic nucleotide gated ion channels in Arabidopsis. Chin K, et al. J Exp Bot, 2010 May. PMID 20378667, Free PMC Article
    4. The chimeric Arabidopsis CYCLIC NUCLEOTIDE-GATED ION CHANNEL11/12 activates multiple pathogen resistance responses. Yoshioka K, et al. Plant Cell, 2006 Mar. PMID 16461580, Free PMC Article
    5. Environmentally sensitive, SA-dependent defense responses in the cpr22 mutant of Arabidopsis. Yoshioka K, et al. Plant J, 2001 May. PMID 11439131

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. residues important for intersubunit interactions of CNGC12 and CNGC11
      Title: A suppressor screen of the chimeric AtCNGC11/12 reveals residues important for intersubunit interactions of cyclic nucleotide-gated ion channels.
    2. AtCNGC11 and 12 mediates a Ca2+ signal that is involved not only in plant immunity, but also in developmental processes such as gravitropic bending and senescence.
      Title: High throughput chemical screening supports the involvement of Ca2+ in cyclic nucleotide-gated ion channel-mediated programmed cell death in Arabidopsis.
    3. AtCNGC11 and 12 gene expression was induced during dark-induced senescence and AtCNGC11 and 12 knockout mutants displayed enhanced chlorophyll loss, which was even more pronounced in the double mutant, also indicating synergistic roles in senescence.
      Title: The cyclic nucleotide-gated channels AtCNGC11 and 12 are involved in multiple Ca²⁺-dependent physiological responses and act in a synergistic manner.
    4. AlphaC-helix in the cyclic nucleotide binding domain is functionally important for CNGC11 and CNGC12.
      Title: Importance of the alphaC-helix in the cyclic nucleotide binding domain for the stable channel regulation and function of cyclic nucleotide gated ion channels in Arabidopsis.
    5. A 3-kb deletion fuses two cyclic nucleotide-gated ion channel (ATCNGC)-encoding genes, ATCNGC11 and ATCNGC12, to generate a novel chimeric gene, ATCNGC11/12.
      Title: The chimeric Arabidopsis CYCLIC NUCLEOTIDE-GATED ION CHANNEL11/12 activates multiple pathogen resistance responses.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_130208.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables monoatomic cation channel activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to bacterium IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to fungus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    cyclic nucleotide-gated channels
    NP_182167.2
    • cyclic nucleotide-gated channels (CNGC11); FUNCTIONS IN: ion channel activity, cyclic nucleotide binding, calmodulin binding, cation channel activity; INVOLVED IN: response to fungus; LOCATED IN: membrane; CONTAINS InterPro DOMAIN/s: Cyclic nucleotide-binding (InterPro:IPR000595), Ion transport (InterPro:IPR005821), Cyclic nucleotide-binding-like (InterPro:IPR018490), RmlC-like jelly roll fold (InterPro:IPR014710); BEST Arabidopsis thaliana protein match is: cyclic nucleotide-gated channel 12 (TAIR:AT2G46450.1); Has 2962 Blast hits to 2888 proteins in 221 species: Archae - 0; Bacteria - 24; Metazoa - 1476; Fungi - 2; Plants - 940; Viruses - 0; Other Eukaryotes - 520 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      19061688..19064937
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001337191.1 → NP_001325416.1  cyclic nucleotide-gated channels [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B370

    2. NM_130208.4 → NP_182167.2  cyclic nucleotide-gated channels [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_182167.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q682T0, Q9SKD6
      UniProtKB/TrEMBL
      A0A178VR19, A0A5S9X7G7
      Conserved Domains (1) summary
      cd00038
      Location:437 → 564
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SKD6.2

    Gene LinkOut

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