Bin1 bridging integrator 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bin1provided by RGD
Official Full Name: bridging integrator 1provided by RGD
Primary source: RGD:621786
See related: EnsemblRapid:ENSRNOG00000012852 AllianceGenome:RGD:621786
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables GTPase binding activity. Involved in positive regulation of GTPase activity; positive regulation of endocytosis; and synaptic vesicle endocytosis. Located in several cellular components, including T-tubule; Z disc; and axon. Is active in glutamatergic synapse. Is extrinsic component of synaptic vesicle membrane. Human ortholog(s) of this gene implicated in breast carcinoma; centronuclear myopathy 2; and prostate adenocarcinoma. Orthologous to human BIN1 (bridging integrator 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Muscle (RPKM 1384.3), Brain (RPKM 390.8) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18p12

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (24282840..24341461)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (24009731..24067267)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (25163575..25222139)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

lower BIN1 levels promote the propagation of Tau pathology by efficiently increasing aggregate internalization by endocytosis and endosomal trafficking.
Title: Loss of Bin1 Promotes the Propagation of Tau Pathology.
AmpII is intricately involved in t-tubule maintenance. Reducing AmpII protein decreases t-tubule density, reduces the amplitude, and increases the heterogeneity of the systolic calcium transient.
Title: Dependence of cardiac transverse tubules on the BAR domain protein amphiphysin II (BIN-1).
Results suggest that Bin1 gene suppression caused by oncogenic E1A via Rb/E2F1 inactivation is an essential step in cell cycle progression promoted by c-Myc, and subsequently, E1A transformation.
Title: Adenovirus E1A oncoprotein liberates c-Myc activity to promote cell proliferation through abating Bin1 expression via an Rb/E2F1-dependent mechanism.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC156129P1 (e-PCR)
- UniSTS:271363

PMC156129P2 (e-PCR)
- UniSTS:271364

RH141034 (e-PCR)
- UniSTS:223034

RH141074 (e-PCR)
- UniSTS:223073

U86405 (e-PCR)
- UniSTS:181108

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables aspartic-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables aspartic-type endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	ISO Inferred from Sequence Orthology more info
enables phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables protease binding	IEA Inferred from Electronic Annotation more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-folding chaperone binding	IEA Inferred from Electronic Annotation more info
enables protein-folding chaperone binding	ISO Inferred from Sequence Orthology more info
enables signaling adaptor activity	IEA Inferred from Electronic Annotation more info
enables signaling adaptor activity	ISO Inferred from Sequence Orthology more info
enables tau protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables tau protein binding	IEA Inferred from Electronic Annotation more info
enables tau protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in T-tubule organization	IEA Inferred from Electronic Annotation more info
involved_in T-tubule organization	ISO Inferred from Sequence Orthology more info
involved_in endosome to lysosome transport	IEA Inferred from Electronic Annotation more info
involved_in endosome to lysosome transport	ISO Inferred from Sequence Orthology more info
involved_in lipid tube assembly	IEA Inferred from Electronic Annotation more info
involved_in lipid tube assembly	ISO Inferred from Sequence Orthology more info
involved_in lipid tube assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of amyloid-beta formation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of amyloid-beta formation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ventricular cardiac muscle cell action potential	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of ventricular cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
involved_in nucleus localization	IEA Inferred from Electronic Annotation more info
involved_in nucleus localization	ISO Inferred from Sequence Orthology more info
involved_in nucleus organization	IEA Inferred from Electronic Annotation more info
involved_in nucleus organization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of GTPase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of actin filament polymerization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of actin filament polymerization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of astrocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of astrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of astrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell cycle process	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell cycle process	ISO Inferred from Sequence Orthology more info
involved_in regulation of endocytosis	IEA Inferred from Electronic Annotation more info
involved_in regulation of heart rate by cardiac conduction	IEA Inferred from Electronic Annotation more info
involved_in regulation of heart rate by cardiac conduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuron differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
involved_in response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic vesicle endocytosis	IEA Inferred from Electronic Annotation more info
involved_in synaptic vesicle endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle endocytosis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in I band	IDA Inferred from Direct Assay more info	PubMed
part_of RNA polymerase II transcription repressor complex	IEA Inferred from Electronic Annotation more info
part_of RNA polymerase II transcription repressor complex	ISO Inferred from Sequence Orthology more info
located_in T-tubule	IDA Inferred from Direct Assay more info	PubMed
located_in T-tubule	IEA Inferred from Electronic Annotation more info
located_in T-tubule	ISO Inferred from Sequence Orthology more info
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IEA Inferred from Electronic Annotation more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axon	ISS Inferred from Sequence or Structural Similarity more info
located_in axon initial segment	IDA Inferred from Direct Assay more info	PubMed
located_in axon terminus	IDA Inferred from Direct Assay more info	PubMed
located_in cerebellar mossy fiber	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in endosome	IEA Inferred from Electronic Annotation more info
is_active_in extrinsic component of synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
part_of lipid tube	IEA Inferred from Electronic Annotation more info
part_of lipid tube	ISO Inferred from Sequence Orthology more info
part_of lipid tube	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in microtubule	ISS Inferred from Sequence or Structural Similarity more info
located_in node of Ranvier	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
located_in presynapse	IEA Inferred from Electronic Annotation more info
is_active_in presynapse	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info
is_active_in synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in varicosity	IDA Inferred from Direct Assay more info	PubMed
located_in vesicle	IEA Inferred from Electronic Annotation more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: myc box-dependent-interacting protein 1

Names: Amph2; amphiphysin II; amphiphysin IIamph2; amphiphysin-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053959.2 → NP_446411.1 myc box-dependent-interacting protein 1

See identical proteins and their annotated locations for NP_446411.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000018

UniProtKB/Swiss-Prot

O08839

UniProtKB/TrEMBL

A6J2Q7, F1LMX1

Related

ENSRNOP00000017573.7, ENSRNOT00000017573.9

Conserved Domains (2) summary

cd07611
Location:31 → 272

BAR_Amphiphysin_I_II; The Bin/Amphiphysin/Rvs (BAR) domain of Amphiphysin I and II

cd12139
Location:516 → 587

SH3_Bin1; Src Homology 3 domain of Bridging integrator 1 (Bin1), also called Amphiphysin-2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086036.1 Reference GRCr8

Range

24282840..24341461

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017600832.2 → XP_017456321.1 myc box-dependent-interacting protein 1 isoform X20
XM_006254505.3 → XP_006254567.1 myc box-dependent-interacting protein 1 isoform X21

See identical proteins and their annotated locations for XP_006254567.1

UniProtKB/TrEMBL

D4ACI3, Q5HZA7

Conserved Domains (2) summary

cd07611
Location:31 → 241

BAR_Amphiphysin_I_II; The Bin/Amphiphysin/Rvs (BAR) domain of Amphiphysin I and II

cd12139
Location:338 → 409

SH3_Bin1; Src Homology 3 domain of Bridging integrator 1 (Bin1), also called Amphiphysin-2
XM_006254504.3 → XP_006254566.1 myc box-dependent-interacting protein 1 isoform X19

UniProtKB/TrEMBL

A0A8J8YMC5

Related

ENSRNOP00000040191.6, ENSRNOT00000049898.6

Conserved Domains (2) summary

cd07611
Location:31 → 241

BAR_Amphiphysin_I_II; The Bin/Amphiphysin/Rvs (BAR) domain of Amphiphysin I and II

cd12139
Location:362 → 433

SH3_Bin1; Src Homology 3 domain of Bridging integrator 1 (Bin1), also called Amphiphysin-2
XM_006254496.4 → XP_006254558.2 myc box-dependent-interacting protein 1 isoform X1

UniProtKB/TrEMBL

F1LMX1

Conserved Domains (3) summary

cd07611
Location:31 → 272

BAR_Amphiphysin_I_II; The Bin/Amphiphysin/Rvs (BAR) domain of Amphiphysin I and II

cd12139
Location:531 → 602

SH3_Bin1; Src Homology 3 domain of Bridging integrator 1 (Bin1), also called Amphiphysin-2

NF033913
Location:387 → 503

fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
XM_006254499.4 → XP_006254561.2 myc box-dependent-interacting protein 1 isoform X4

UniProtKB/TrEMBL

F1LMX1

Conserved Domains (2) summary

cd12139
Location:451 → 522

SH3_Bin1; Src Homology 3 domain of Bridging integrator 1 (Bin1), also called Amphiphysin-2

cl12013
Location:31 → 272

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_006254500.4 → XP_006254562.2 myc box-dependent-interacting protein 1 isoform X7

UniProtKB/TrEMBL

F1LMX1

Conserved Domains (2) summary

cd12139
Location:427 → 498

SH3_Bin1; Src Homology 3 domain of Bridging integrator 1 (Bin1), also called Amphiphysin-2

cl12013
Location:31 → 272

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_006254502.4 → XP_006254564.2 myc box-dependent-interacting protein 1 isoform X10

Conserved Domains (2) summary

cd12139
Location:408 → 479

SH3_Bin1; Src Homology 3 domain of Bridging integrator 1 (Bin1), also called Amphiphysin-2

cl12013
Location:31 → 272

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_039096554.2 → XP_038952482.1 myc box-dependent-interacting protein 1 isoform X14

Conserved Domains (2) summary

cd12139
Location:384 → 455

SH3_Bin1; Src Homology 3 domain of Bridging integrator 1 (Bin1), also called Amphiphysin-2

cl12013
Location:31 → 272

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_039096550.2 → XP_038952478.1 myc box-dependent-interacting protein 1 isoform X3

UniProtKB/TrEMBL

F1LMX1

Related

ENSRNOP00000101123.1, ENSRNOT00000127521.1

Conserved Domains (3) summary

cd07611
Location:31 → 272

BAR_Amphiphysin_I_II; The Bin/Amphiphysin/Rvs (BAR) domain of Amphiphysin I and II

cd12139
Location:480 → 551

SH3_Bin1; Src Homology 3 domain of Bridging integrator 1 (Bin1), also called Amphiphysin-2

pfam05109
Location:317 → 505

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
XM_017600830.3 → XP_017456319.2 myc box-dependent-interacting protein 1 isoform X6

UniProtKB/TrEMBL

F1LMX1

Conserved Domains (2) summary

cd12139
Location:436 → 507

SH3_Bin1; Src Homology 3 domain of Bridging integrator 1 (Bin1), also called Amphiphysin-2

cl12013
Location:31 → 272

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_063277073.1 → XP_063133143.1 myc box-dependent-interacting protein 1 isoform X9
XM_017600831.3 → XP_017456320.2 myc box-dependent-interacting protein 1 isoform X13

Conserved Domains (2) summary

cd12139
Location:393 → 464

SH3_Bin1; Src Homology 3 domain of Bridging integrator 1 (Bin1), also called Amphiphysin-2

cl12013
Location:31 → 272

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_039096556.2 → XP_038952484.1 myc box-dependent-interacting protein 1 isoform X18

UniProtKB/TrEMBL

A0A8I5Y9B3

Related

ENSRNOP00000077086.1, ENSRNOT00000105880.2

Conserved Domains (2) summary

cd12139
Location:369 → 440

SH3_Bin1; Src Homology 3 domain of Bridging integrator 1 (Bin1), also called Amphiphysin-2

cl12013
Location:31 → 272

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_006254501.3 → XP_006254563.1 myc box-dependent-interacting protein 1 isoform X8

UniProtKB/TrEMBL

D4A4P1

Conserved Domains (2) summary

cd07611
Location:31 → 241

BAR_Amphiphysin_I_II; The Bin/Amphiphysin/Rvs (BAR) domain of Amphiphysin I and II

cd12139
Location:420 → 491

SH3_Bin1; Src Homology 3 domain of Bridging integrator 1 (Bin1), also called Amphiphysin-2
XM_063277074.1 → XP_063133144.1 myc box-dependent-interacting protein 1 isoform X12
XM_008772014.2 → XP_008770236.1 myc box-dependent-interacting protein 1 isoform X17

Related

ENSRNOP00000100862.1, ENSRNOT00000136210.1

Conserved Domains (2) summary

cd07611
Location:31 → 241

BAR_Amphiphysin_I_II; The Bin/Amphiphysin/Rvs (BAR) domain of Amphiphysin I and II

cd12139
Location:377 → 448

SH3_Bin1; Src Homology 3 domain of Bridging integrator 1 (Bin1), also called Amphiphysin-2
XM_006254497.3 → XP_006254559.1 myc box-dependent-interacting protein 1 isoform X2

UniProtKB/TrEMBL

D4A4P1

Related

ENSRNOP00000042320.5, ENSRNOT00000042287.8

Conserved Domains (2) summary

cd07611
Location:31 → 241

BAR_Amphiphysin_I_II; The Bin/Amphiphysin/Rvs (BAR) domain of Amphiphysin I and II

cd12139
Location:485 → 556

SH3_Bin1; Src Homology 3 domain of Bridging integrator 1 (Bin1), also called Amphiphysin-2
XM_063277071.1 → XP_063133141.1 myc box-dependent-interacting protein 1 isoform X5
XM_006254503.3 → XP_006254565.1 myc box-dependent-interacting protein 1 isoform X11

UniProtKB/TrEMBL

A0A8I6A3N4, D4A4P1

Related

ENSRNOP00000087136.1, ENSRNOT00000096264.2

Conserved Domains (2) summary

cd07611
Location:31 → 241

BAR_Amphiphysin_I_II; The Bin/Amphiphysin/Rvs (BAR) domain of Amphiphysin I and II

cd12139
Location:405 → 476

SH3_Bin1; Src Homology 3 domain of Bridging integrator 1 (Bin1), also called Amphiphysin-2
XM_039096555.2 → XP_038952483.1 myc box-dependent-interacting protein 1 isoform X15

UniProtKB/TrEMBL

A0A8I6ANM7

Related

ENSRNOP00000094103.1, ENSRNOT00000119810.2

Conserved Domains (2) summary

cd07611
Location:31 → 241

BAR_Amphiphysin_I_II; The Bin/Amphiphysin/Rvs (BAR) domain of Amphiphysin I and II

cd12139
Location:381 → 452

SH3_Bin1; Src Homology 3 domain of Bridging integrator 1 (Bin1), also called Amphiphysin-2
XM_063277075.1 → XP_063133145.1 myc box-dependent-interacting protein 1 isoform X16

Related

ENSRNOP00000097221.2, ENSRNOT00000111732.2
XM_063277077.1 → XP_063133147.1 myc box-dependent-interacting protein 1 isoform X22
XM_063277078.1 → XP_063133148.1 myc box-dependent-interacting protein 1 isoform X23

UniProtKB/TrEMBL

A0A8I6AU27