Pfdn4 prefoldin subunit 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pfdn4provided by RGD
Official Full Name: prefoldin subunit 4provided by RGD
Primary source: RGD:2324021
See related: EnsemblRapid:ENSRNOG00000050932 AllianceGenome:RGD:2324021
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable amyloid-beta binding activity and unfolded protein binding activity. Predicted to be involved in negative regulation of amyloid fibril formation and protein folding. Predicted to be located in mitochondrion and nucleus. Predicted to be part of prefoldin complex. Predicted to be active in cytoplasm. Orthologous to human PFDN4 (prefoldin subunit 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 143.2), Kidney (RPKM 121.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q42

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (179721765..179729901)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (159303173..159311221)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (168124634..168132739)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

PMC61082P1 (e-PCR)
- UniSTS:273409

RH134447 (e-PCR)
- UniSTS:217727

Cyp24 (e-PCR), detects polymorphism
- UniSTS:141449

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables amyloid-beta binding	ISO Inferred from Sequence Orthology more info
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables unfolded protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of amyloid fibril formation	ISO Inferred from Sequence Orthology more info
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein folding	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of prefoldin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of prefoldin complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: prefoldin subunit 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001399732.2 → NP_001386661.2 prefoldin subunit 4 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003
NM_001399733.2 → NP_001386662.2 prefoldin subunit 4 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003