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    SNX2b sorting nexin 2B [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 830603, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SNX2b
    Official Full Name
    sorting nexin 2B
    Primary source
    TAIR:AT5G07120
    Locus tag
    AT5G07120
    See related
    Araport:AT5G07120
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    sorting nexin 2B; T28J14.60; T28J14_60
    Summary
    Encodes sorting nexin SNX2b. SNX2b is peripherally associated with membranes. Involved in vesicular trafficking from endosomes to the vacuole.
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    Genomic context

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    See SNX2b in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    5
    Sequence:
    Chromosome: 5; NC_003076.8 (2206894..2209556, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene WRKY DNA-binding protein 26 Neighboring gene prenylated RAB acceptor 1.B6 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene laccase 13 Neighboring gene tRNA-Gly

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overexpression of Arabidopsis sorting nexin AtSNX2b inhibits endocytic trafficking to the vacuole. Phan NQ, et al. Mol Plant, 2008 Nov. PMID 19825596
    2. Overexpression of FAB1A-GFP recruits SNX2b on the endosome membrane in snx1-1 mutant in Arabidopsis. Hirano T, et al. Plant Signal Behav, 2016. PMID 26515455, Free PMC Article
    3. Analyses of sorting nexins reveal distinct retromer-subcomplex functions in development and protein sorting in Arabidopsis thaliana. Pourcher M, et al. Plant Cell, 2010 Dec. PMID 21156856, Free PMC Article
    4. Plant retromer, localized to the prevacuolar compartment and microvesicles in Arabidopsis, may interact with vacuolar sorting receptors. Oliviusson P, et al. Plant Cell, 2006 May. PMID 16582012, Free PMC Article
    5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. overexpression of FAB1A-GFP reassembles SNX2b-mRFP on the endosomal membrane despite the absence of SNX1.
      Title: Overexpression of FAB1A-GFP recruits SNX2b on the endosome membrane in snx1-1 mutant in Arabidopsis.
    2. AtSNX2b is involved in vesicular trafficking from endosomes to the vacuole. [AtSNX2b]
      Title: Overexpression of Arabidopsis sorting nexin AtSNX2b inhibits endocytic trafficking to the vacuole.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    NM_001342920.1
    NM_001342921.1
    NM_120794.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within developmental process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in late endosome to vacuole transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within seedling development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in multivesicular body membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    part_of retromer complex TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sorting nexin 2B
    NP_196329.2
    • sorting nexin 2B (SNX2b); FUNCTIONS IN: phospholipid binding; INVOLVED IN: vesicle-mediated transport, intracellular signaling pathway; LOCATED IN: membrane; EXPRESSED IN: cultured cell; CONTAINS InterPro DOMAIN/s: Vps5 C-terminal (InterPro:IPR015404), Phox-like (InterPro:IPR001683); BEST Arabidopsis thaliana protein match is: sorting nexin 2A (TAIR:AT5G58440.1); Has 2399 Blast hits to 2386 proteins in 279 species: Archae - 13; Bacteria - 100; Metazoa - 1366; Fungi - 555; Plants - 146; Viruses - 0; Other Eukaryotes - 219 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      2206894..2209556 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_120794.4 → NP_196329.2  sorting nexin 2B [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196329.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DFS6, Q0WLC3, Q570X1, Q9LYQ3
      UniProtKB/TrEMBL
      A0A5S9Y2E5, A0A654FZ53
      Conserved Domains (2) summary
      cd06865
      Location:143 → 263
      PX_SNX_like; The phosphoinositide binding Phox Homology domain of SNX-like proteins
      cd07596
      Location:335 → 563
      BAR_SNX; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexins

    2. NM_001342920.1 → NP_001331853.1  sorting nexin 2B [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DFS6, Q0WLC3, Q570X1, Q9LYQ3
      UniProtKB/TrEMBL
      A0A5S9Y2E5, A0A654FZ53
      Conserved Domains (2) summary
      cd06865
      Location:143 → 263
      PX_SNX_like; The phosphoinositide binding Phox Homology domain of SNX-like proteins
      cd07596
      Location:335 → 563
      BAR_SNX; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexins

    3. NM_001342921.1 → NP_001331854.1  sorting nexin 2B [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BF56, A0A5S9Y2E5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B9DFS6.1

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