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    B4galt7 beta-1,4-galactosyltransferase 7 [ Mus musculus (house mouse) ]

    Gene ID: 218271, updated on 27-Nov-2024

    Summary

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    Official Symbol
    B4galt7provided by MGI
    Official Full Name
    beta-1,4-galactosyltransferase 7provided by MGI
    Primary source
    MGI:MGI:2384987
    See related
    Ensembl:ENSMUSG00000021504 AllianceGenome:MGI:2384987
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    XGPT; XGalT-1
    Summary
    Enables xylosylprotein 4-beta-galactosyltransferase activity. Involved in glycosaminoglycan biosynthetic process. Predicted to be located in membrane. Predicted to be active in Golgi apparatus. Is expressed in several structures, including central nervous system and retina. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome and Ehlers-Danlos syndrome spondylodysplastic type 1. Orthologous to human B4GALT7 (beta-1,4-galactosyltransferase 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 11.8), limb E14.5 (RPKM 11.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See B4galt7 in Genome Data Viewer
    Location:
    13 B1; 13 30.06 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (55747709..55758258)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (55599896..55610443)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31364 Neighboring gene transmembrane p24 trafficking protein 9 Neighboring gene calcium modulating ligand Neighboring gene DEAD box helicase 46

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A quantitative study of the Golgi retention of glycosyltransferases. Sun X, et al. J Cell Sci, 2021 Oct 15. PMID 34533190
    2. Biochemical and thermodynamic characterization of mutated β1,4-galactosyltransferase 7 involved in the progeroid form of the Ehlers-Danlos syndrome. Rahuel-Clermont S, et al. Biochem J, 2010 Dec 1. PMID 20809901
    3. LDLRAD3 is a receptor for Venezuelan equine encephalitis virus. Ma H, et al. Nature, 2020 Dec. PMID 33208938, Free PMC Article
    4. Apoptosis and involution in the mammary gland are altered in mice lacking a novel receptor, beta1,4-Galactosyltransferase I. de la Cruz L, et al. Dev Biol, 2004 Aug 15. PMID 15282149
    5. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. surface GalT I might negatively regulate mammary epithelial cell survival
      Title: Apoptosis and involution in the mammary gland are altered in mice lacking a novel receptor, beta1,4-Galactosyltransferase I.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC28643

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables galactosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables galactosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables manganese ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables manganese ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables xylosylprotein 4-beta-galactosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables xylosylprotein 4-beta-galactosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables xylosylprotein 4-beta-galactosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables xylosylprotein 4-beta-galactosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycosaminoglycan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycosaminoglycan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycosaminoglycan biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of fibroblast proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein N-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein N-linked glycosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proteoglycan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteoglycan metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteoglycan metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in supramolecular fiber organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in supramolecular fiber organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    beta-1,4-galactosyltransferase 7
    Names
    UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 7
    UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 7
    UDP-galactose:beta-xylose beta-1,4-galactosyltransferase
    b4Gal-T7
    beta-1,4-GalTase 7
    beta4Gal-T7
    proteoglycan UDP-galactose:beta-xylose beta1,4-galactosyltransferase I
    xylosylprotein 4-beta-galactosyltransferase
    xylosylprotein beta-1,4-galactosyltransferase
    xylosylprotein beta1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I)
    NP_001298066.1
    NP_666157.1
    XP_036013888.1
    XP_036013889.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001311137.1 → NP_001298066.1  beta-1,4-galactosyltransferase 7 isoform 2

      See identical proteins and their annotated locations for NP_001298066.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
      Source sequence(s)
      BC055703, BF455923
      Consensus CDS
      CCDS79190.1
      UniProtKB/TrEMBL
      Q3UR73
      Related
      ENSMUSP00000098327.4, ENSMUST00000100764.10
      Conserved Domains (1) summary
      cd00899
      Location:92 → 280
      b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

    2. NM_146045.2 → NP_666157.1  beta-1,4-galactosyltransferase 7 isoform 1

      See identical proteins and their annotated locations for NP_666157.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK146855, BC055703, BF455923
      Consensus CDS
      CCDS26550.1
      UniProtKB/Swiss-Prot
      Q7TNU3, Q8R087
      UniProtKB/TrEMBL
      Q3TAW1, Q3UR73
      Related
      ENSMUSP00000068532.7, ENSMUST00000064701.8
      Conserved Domains (1) summary
      cd00899
      Location:92 → 315
      b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      55747709..55758258
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157995.1 → XP_036013888.1  beta-1,4-galactosyltransferase 7 isoform X1

      UniProtKB/TrEMBL
      Q3UR73
      Related
      ENSMUSP00000123292.2, ENSMUST00000133176.8
      Conserved Domains (1) summary
      cd00899
      Location:36 → 259
      b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

    2. XM_036157996.1 → XP_036013889.1  beta-1,4-galactosyltransferase 7 isoform X2

      UniProtKB/TrEMBL
      D3Z065
      Conserved Domains (1) summary
      cd00899
      Location:36 → 224
      b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R087.1 GenPept UniProtKB/Swiss-Prot:Q8R087

    Gene LinkOut

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