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    Trp73 transformation related protein 73 [ Mus musculus (house mouse) ]

    Gene ID: 22062, updated on 9-Dec-2024

    Summary

    Official Symbol
    Trp73provided by MGI
    Official Full Name
    transformation related protein 73provided by MGI
    Primary source
    MGI:MGI:1336991
    See related
    Ensembl:ENSMUSG00000029026 AllianceGenome:MGI:1336991
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p73; Tp73; TAp73; deltaNp73
    Summary
    This gene encodes tumor protein p73, which is a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include p53, p63, and p73 and have high sequence similarity to one another, which allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways involving direct or indirect protein interactions, resulting in regulation of the same target gene promoters or regulation of each other's promoters. The p73 protein is expressed at very low levels in normal tissues and is differentially expressed in a number of tumors. The p73 gene expresses at least 35 mRNA variants due to the use of alternate promoters, alternate translation initiation sites, and multiple splice variations. Theoretically this can account for 29 different p73 isoforms; however, the biological validity and the full-length nature of most variants have not been determined. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in lung adult (RPKM 1.7), ovary adult (RPKM 1.4) and 13 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Trp73 in Genome Data Viewer
    Location:
    4 E2; 4 83.79 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (154140706..154224332, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (154056249..154139875, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 47 Neighboring gene small integral membrane protein 1 Neighboring gene coiled-coil domain containing 27 Neighboring gene STARR-seq mESC enhancer starr_12227 Neighboring gene STARR-seq mESC enhancer starr_12228 Neighboring gene STARR-positive B cell enhancer ABC_E4737 Neighboring gene predicted gene, 26036 Neighboring gene WD repeat containing, antisense to Trp73 Neighboring gene STARR-positive B cell enhancer ABC_E1045 Neighboring gene transformation related protein 63 regulated 1 like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables MDM2/MDM4 family protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables p53 binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription cis-regulatory region binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription corepressor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cerebrospinal fluid secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within digestive tract morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within forebrain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within hippocampus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within negative regulation of cardiac muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of neuron apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuron development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of apoptotic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of cell size IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of lung ciliated cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of oligodendrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within post-embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein tetramerization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_negative_effect regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within regulation of neuron apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001126330.1NP_001119802.1  tumor protein p73 isoform b

      See identical proteins and their annotated locations for NP_001119802.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is an alternate promoter product; it lacks a few of 5' exons but has an alternate 5' exon, as compared to variant 1. The resulting isoform b, also known as DNp73alpha, has a shorter and different N-terminus, as compared to isoform a.
      Source sequence(s)
      AK014503, AK139633, Y19235
      Consensus CDS
      CCDS51397.1
      UniProtKB/TrEMBL
      Z4YK94
      Related
      ENSMUSP00000114418.2, ENSMUST00000133533.8
      Conserved Domains (5) summary
      cd09571
      Location:440504
      SAM_tumor-p73; SAM domain of tumor-p73 proteins
      smart00454
      Location:444504
      SAM; Sterile alpha motif
      pfam00870
      Location:64260
      P53; P53 DNA-binding domain
      pfam07710
      Location:296335
      P53_tetramer; P53 tetramerization motif
      pfam09646
      Location:499589
      Gp37; Gp37 protein
    2. NM_001126331.1NP_001119803.1  tumor protein p73 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) is an alternate promoter product; it lacks a few of 5' exons and two internal exons in the 3' region, but has an alternate 5' exon, as compared to variant 1. The resulting isoform c, also known as DNp73zeta, has a shorter and different N-terminus and lacks an internal segment in the C-terminal region, as compared to isoform a.
      Source sequence(s)
      AK014503, AK017412, AK139633
      Consensus CDS
      CCDS51396.1
      UniProtKB/Swiss-Prot
      Q9JJP2
      UniProtKB/TrEMBL
      Q9D6A3
      Related
      ENSMUSP00000095368.5, ENSMUST00000097762.11
      Conserved Domains (5) summary
      smart00454
      Location:353408
      SAM; Sterile alpha motif
      pfam00870
      Location:64260
      P53; P53 DNA-binding domain
      pfam07710
      Location:296335
      P53_tetramer; P53 tetramerization motif
      pfam09646
      Location:403493
      Gp37; Gp37 protein
      cl15755
      Location:353408
      SAM_superfamily; SAM (Sterile alpha motif )
    3. NM_011642.4NP_035772.3  tumor protein p73 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform a, also known as TAp73alpha.
      Source sequence(s)
      AL806525
      Consensus CDS
      CCDS19009.2
      UniProtKB/Swiss-Prot
      B1AX89, B1AX90, Q3UT91, Q9CU77, Q9JJP1, Q9JJP2, Q9WUJ0
      UniProtKB/TrEMBL
      Z4YK94
      Related
      ENSMUSP00000101269.4, ENSMUST00000105644.10
      Conserved Domains (4) summary
      cd09571
      Location:481545
      SAM_tumor-p73; SAM domain of tumor-p73 proteins
      pfam00870
      Location:105301
      P53; P53 DNA-binding domain
      pfam07710
      Location:338376
      P53_tetramer; P53 tetramerisation motif
      pfam09646
      Location:540630
      Gp37; Gp37 protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      154140706..154224332 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538720.2XP_006538783.2  tumor protein p73 isoform X1

      UniProtKB/TrEMBL
      Z4YK94
      Conserved Domains (4) summary
      cd08367
      Location:137316
      P53; P53 DNA-binding domain
      cd09571
      Location:499563
      SAM_tumor-p73; SAM domain of tumor-p73 proteins
      pfam07710
      Location:356392
      P53_tetramer; P53 tetramerisation motif
      pfam09646
      Location:558648
      Gp37; Gp37 protein
    2. XM_006538722.5XP_006538785.1  tumor protein p73 isoform X2

      See identical proteins and their annotated locations for XP_006538785.1

      UniProtKB/TrEMBL
      Z4YK94
      Conserved Domains (4) summary
      cd08367
      Location:56235
      P53; P53 DNA-binding domain
      cd09571
      Location:418482
      SAM_tumor-p73; SAM domain of tumor-p73 proteins
      pfam07710
      Location:275311
      P53_tetramer; P53 tetramerisation motif
      pfam09646
      Location:477567
      Gp37; Gp37 protein
    3. XM_006538723.3XP_006538786.1  tumor protein p73 isoform X3

      Conserved Domains (4) summary
      cd08367
      Location:4101
      P53; P53 DNA-binding domain
      cd09571
      Location:284348
      SAM_tumor-p73; SAM domain of tumor-p73 proteins
      pfam07710
      Location:141177
      P53_tetramer; P53 tetramerisation motif
      pfam09646
      Location:343433
      Gp37; Gp37 protein