MPK2 mitogen-activated protein kinase homolog 2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: MPK2
Official Full Name: mitogen-activated protein kinase homolog 2
Primary source: TAIR:AT1G59580
Locus tag: AT1G59580
See related: Araport:AT1G59580
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATMPK2; mitogen-activated protein kinase homolog 2; MITOGEN-ACTIVATED PROTEIN KINASE HOMOLOG 2; T30E16.13; T30E16_13
Summary: encodes a mitogen-activated kinase involved in innate immunity
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Genomic context

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See MPK2 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 3

Sequence:: Chromosome: 1; NC_003070.9 (21884018..21886051)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AtMKP2, a novel MKP protein in Arabidopsis, acts upon MPK3 and -6, and serves as a positive regulator of the cellular response to oxidant challenge
Title: Arabidopsis MAPK phosphatase 2 (MKP2) positively regulates oxidative stress tolerance and inactivates the MPK3 and MPK6 MAPKs.
Regulation of AtMPK1/2 kinase activity in Arabidopsis might be under the control of signals involved in different kinds of stress.
Title: Diverse stress signals activate the C1 subgroup MAP kinases of Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_104651.5

Supported by ESTs:

NM_202320.1

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables MAP kinase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to wounding	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within signal transduction	IC Inferred by Curator more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: mitogen-activated protein kinase homolog 2

NP_564746.1

mitogen-activated protein kinase homolog 2 (MPK2); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), MAP kinase, conserved site (InterPro:IPR003527), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: mitogen-activated protein kinase 1 (TAIR:AT1G10210.2); Has 121192 Blast hits to 119674 proteins in 4402 species: Archae - 98; Bacteria - 12397; Metazoa - 46062; Fungi - 12260; Plants - 29633; Viruses - 469; Other Eukaryotes - 20273 (source: NCBI BLink).

NP_974049.1

mitogen-activated protein kinase homolog 2 (MPK2); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), MAP kinase, conserved site (InterPro:IPR003527), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: mitogen-activated protein kinase 1 (TAIR:AT1G10210.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

21884018..21886051

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_104651.5 → NP_564746.1 mitogen-activated protein kinase homolog 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_564746.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q39022, Q9LQ58

UniProtKB/TrEMBL

A0A178WBY0, A0A5S9WMU7

Conserved Domains (1) summary

cd07858
Location:26 → 363

STKc_TEY_MAPK; Catalytic domain of the Serine/Threonine Kinases, Plant TEY Mitogen-Activated Protein Kinases
NM_202320.1 → NP_974049.1 mitogen-activated protein kinase homolog 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_974049.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q39022, Q9LQ58

UniProtKB/TrEMBL

A0A178WBY0, A0A5S9WMU7

Conserved Domains (1) summary

cd07858
Location:26 → 363

STKc_TEY_MAPK; Catalytic domain of the Serine/Threonine Kinases, Plant TEY Mitogen-Activated Protein Kinases