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    Prx3 Peroxiredoxin 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42109, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Prx3provided by FlyBase
    Official Full Name
    Peroxiredoxin 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0038519
    Locus tag
    Dmel_CG5826
    See related
    AllianceGenome:FB:FBgn0038519
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5826; Dmel\CG5826; dPRDX3; dprx3; dPrx3; DPx-5037; DPx5037; mTPx; mtTPx; peroxiredoxin 5037; Prx5037
    Summary
    Enables thioredoxin-dependent peroxiredoxin activity. Involved in several processes, including cell redox homeostasis; determination of adult lifespan; and hydrogen peroxide catabolic process. Located in mitochondrion. Is expressed in adult head; adult heart; adult thorax; and organism. Used to study autosomal recessive spinocerebellar ataxia 32. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 32. Orthologous to human PRDX3 (peroxiredoxin 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Prx3 in Genome Data Viewer
    Location:
    90B4-90B4; 3-61 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (17545222..17546531, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (13370944..13372253, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene lethal (3) 07882 Neighboring gene Pyrroline-5-carboxylate reductase-like 2 Neighboring gene Splicing factor 1 Neighboring gene H6-like-homeobox Neighboring gene Sgs5bis

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. 5-Aminolevulinic acid bypasses mitochondrial complex I deficiency and corrects physiological dysfunctions in Drosophila. Nozawa N, et al. Hum Mol Genet, 2023 Aug 7. PMID 37364055, Free PMC Article
    2. Involvement of Prx3, a Drosophila ortholog of the thiol-dependent peroxidase PRDX3, in age-dependent oxidative stress resistance. Kayashima Y, et al. Biomed Res, 2012. PMID 23124252
    3. Mitochondrial Redox Signaling Is Critical to the Normal Functioning of the Neuronal System. Odnokoz O, et al. Front Cell Dev Biol, 2021. PMID 33585478, Free PMC Article
    4. Supplementation with hydrogen-producing composition confers beneficial effects on physiology and life span in Drosophila. Klichko VI, et al. Heliyon, 2019 May. PMID 31193183, Free PMC Article
    5. Biallelic loss-of-function variations in PRDX3 cause cerebellar ataxia. Rebelo AP, et al. Brain, 2021 Jun 22. PMID 33889951

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Biallelic loss-of-function variations in PRDX3 cause cerebellar ataxia.
      Title: Biallelic loss-of-function variations in PRDX3 cause cerebellar ataxia.
    2. Data shows that LRRK2 inhibits PRDX3 in the fly brain.
      Title: Thiol peroxidases ameliorate LRRK2 mutant-induced mitochondrial and dopaminergic neuronal degeneration in Drosophila.
    3. Prx3 plays an important role in the oxidative stress response and is involved in the age-dependent competence of the oxidative stress response.
      Title: Involvement of Prx3, a Drosophila ortholog of the thiol-dependent peroxidase PRDX3, in age-dependent oxidative stress resistance.
    4. flies underexpressing peroxiredoxin 3 and peroxiredoxin 5 showed an 80% reduction in lifespan and a massive induction of apoptosis in the muscle and digestive system tissues.
      Title: Mitochondrial peroxiredoxins are critical for the maintenance of redox state and the survival of adult Drosophila.
    5. While the upstream CG7215 gene can be expressed from both mono- and dicistronic mRNAs, the downstream dPrx5 gene is likely to be expressed predominantly from its monocistronic transcripts.
      Title: Drosophila peroxiredoxin 5 is the second gene in a dicistronic operon.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables peroxiredoxin activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peroxiredoxin activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thioredoxin peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thioredoxin-dependent peroxiredoxin activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell redox homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell redox homeostasis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in determination of adult lifespan IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in hydrogen peroxide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in hydrogen peroxide catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrial matrix TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    peroxiredoxin 3
    Names
    CG5826-PA
    Prx3-PA
    mitochondrial peroxiredoxin
    peroxiredoxin 5037
    thioredoxin peroxidase 3
    thioredoxin-peroxidase-3
    NP_524387.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      17545222..17546531 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079663.3 → NP_524387.1  peroxiredoxin 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524387.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9GPQ3, Q9VEJ0
      Related
      FBpp0082927
      Conserved Domains (3) summary
      COG0450
      Location:40 → 233
      AhpC; Alkyl hydroperoxide reductase subunit AhpC (peroxiredoxin) [Defense mechanisms]
      cd03015
      Location:42 → 212
      PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...
      pfam10417
      Location:195 → 232
      1-cysPrx_C; C-terminal domain of 1-Cys peroxiredoxin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VEJ0.2 Q9VEJ0

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