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    Sems Seminase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40315, updated on 9-Dec-2024

    Summary

    Official Symbol
    Semsprovided by FlyBase
    Official Full Name
    Seminaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037036
    Locus tag
    Dmel_CG10586
    See related
    AllianceGenome:FB:FBgn0037036
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10586; Dmel\CG10586; sems; SP168
    Summary
    Enables serine hydrolase activity. Involved in negative regulation of female receptivity, post-mating; sperm storage; and zymogen activation. Located in extracellular space. Is expressed in adult head and male accessory gland. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Sems in Genome Data Viewer
    Location:
    78A1-78A1; 3-47 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20955755..20956750, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20948855..20949850, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene fringe Neighboring gene long non-coding RNA:CR45243 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    General gene information

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    located_in extracellular space PubMed 

    General protein information

    Preferred Names
    seminase
    Names
    CG10586-PA
    Sems-PA
    NP_649270.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      20955755..20956750 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141013.2 → NP_649270.1  seminase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649270.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C1C3F2, Q4QQ23, Q4QQ30, Q9VP95
      Related
      FBpp0077991
      Conserved Domains (2) summary
      smart00020
      Location:43 → 263
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:44 → 265
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
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