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    CG4907 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42686, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG4907provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039010
    Locus tag
    Dmel_CG4907
    See related
    AllianceGenome:FB:FBgn0039010
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG4907
    Summary
    Predicted to enable mannose-ethanolamine phosphotransferase activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in multiple congenital anomalies-hypotonia-seizures syndrome 1. Orthologous to human PIGN (phosphatidylinositol glycan anchor biosynthesis class N). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG4907 in Genome Data Viewer
    Location:
    94C2-94C2; 3-76 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22707786..22710762, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18533508..18536484, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Crustacean cardioactive peptide Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene winged eye Neighboring gene Iron regulatory protein 1A Neighboring gene antisense RNA:CR45648

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Involvement of winged eye encoding a chromatin-associated bromo-adjacent homology domain protein in disc specification. Katsuyama T, et al. Proc Natl Acad Sci U S A, 2005 Nov 1. PMID 16247005, Free PMC Article
    2. The RNA export factor, Nxt1, is required for tissue specific transcriptional regulation. Caporilli S, et al. PLoS Genet, 2013 Jun. PMID 23754955, Free PMC Article
    3. Quantitative proteomics and phosphoproteomics reveal insights into mechanisms of ocnus function in Drosophila testis development. Zheng Y, et al. BMC Genomics, 2023 May 26. PMID 37237333, Free PMC Article
    4. Identification of GOLPH3 Partners in Drosophila Unveils Potential Novel Roles in Tumorigenesis and Neural Disorders. Sechi S, et al. Cells, 2021 Sep 6. PMID 34571985, Free PMC Article
    5. The genetic basis for variation in olfactory behavior in Drosophila melanogaster. Arya GH, et al. Chem Senses, 2015 May. PMID 25687947, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables mannose-ethanolamine phosphotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mannose-ethanolamine phosphotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG4907-PA
    NP_651086.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      22707786..22710762 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142829.3 → NP_651086.1  uncharacterized protein Dmel_CG4907 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651086.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IHE6, Q9VCV7
      Related
      FBpp0083723
      Conserved Domains (2) summary
      pfam04987
      Location:413 → 858
      PigN; Phosphatidylinositolglycan class N (PIG-N)
      cd16020
      Location:42 → 327
      GPI_EPT_1; GPI ethanolamine phosphate transferase 1; PIG-N
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IHE6 Q8IHE6
    Q8T3S3 Q8T3S3
    Q9VCV7 Q9VCV7

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