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    Mal-A6 Maltase A6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 246565, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mal-A6provided by FlyBase
    Official Full Name
    Maltase A6provided by FlyBase
    Primary source
    FLYBASE:FBgn0050360
    Locus tag
    Dmel_CG30360
    See related
    AllianceGenome:FB:FBgn0050360
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG30360; CG8689; Dmel\CG30360; Drome_A6; mal-A6; mal_A6
    Summary
    Predicted to enable alpha-1,4-glucosidase activity. Predicted to be involved in carbohydrate metabolic process. Is expressed in adult head. Human ortholog(s) of this gene implicated in cystinuria. Orthologous to human SLC3A1 (solute carrier family 3 member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mal-A6 in Genome Data Viewer
    Location:
    44D1-44D1; 2-59 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8465158..8467595)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4352663..4355100)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Maltase A4 Neighboring gene Maltase A5 Neighboring gene Maltase A7 Neighboring gene Maltase A8 Neighboring gene mangetout

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial Dysfunction Plus High-Sugar Diet Provokes a Metabolic Crisis That Inhibits Growth. Kemppainen E, et al. PLoS One, 2016. PMID 26812173, Free PMC Article
    2. Association between duplicated maltase genes and the transcriptional regulation for the carbohydrate changes in Drosophila melanogaster. Inomata N, et al. Gene, 2019 Feb 20. PMID 30399425
    3. Small Maf functions in the maintenance of germline stem cells in the Drosophila testis. Tan SWS, et al. Redox Biol, 2018 May. PMID 29245136, Free PMC Article
    4. Differential gene expression by RNA-seq during Alzheimer's disease-like progression in the Drosophila melanogaster model. da Costa Silva JR, et al. Neurosci Res, 2022 Jul. PMID 35219723
    5. Assessment of genome-wide protein function classification for Drosophila melanogaster. Mi H, et al. Genome Res, 2003 Sep. PMID 12952880, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables alpha-1,4-glucosidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    maltase A6
    Names
    CG30360-PC
    CG30360-PD
    Mal-A6-PC
    Mal-A6-PD
    NP_724679.2
    NP_995779.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8465158..8467595
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165608.2 → NP_724679.2  maltase A6, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724679.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7F1, G4LU71
      Conserved Domains (2) summary
      cd11328
      Location:40 → 516
      AmyAc_maltase; Alpha amylase catalytic domain found in maltase (also known as alpha glucosidase) and related proteins
      TIGR02403
      Location:43 → 599
      trehalose_treC; alpha,alpha-phosphotrehalase

    2. NM_206057.3 → NP_995779.2  maltase A6, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995779.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7F1, G4LU71
      Conserved Domains (2) summary
      cd11328
      Location:40 → 516
      AmyAc_maltase; Alpha amylase catalytic domain found in maltase (also known as alpha glucosidase) and related proteins
      TIGR02403
      Location:43 → 599
      trehalose_treC; alpha,alpha-phosphotrehalase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z7F1 A1Z7F1

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