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    CG10345 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42017, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG10345provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027562
    Locus tag
    Dmel_CG10345
    See related
    AllianceGenome:FB:FBgn0027562
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA; BcDNA:GH08773; Dmel\CG10345
    Summary
    Predicted to enable scavenger receptor activity. Involved in defense response to protozoan. Predicted to be active in membrane. Is expressed in embryonic/larval anterior spiracle; embryonic/larval garland cell; and testis. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy 4. Orthologous to human SCARB2 (scavenger receptor class B member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG10345 in Genome Data Viewer
    Location:
    89D5-89D5; 3-59 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (16597073..16604861, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12422795..12430583, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Sarcoplasmic calcium-binding protein 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene neuropeptide F Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression of the Scavenger Receptor Class B type I (SR-BI) family in Drosophila melanogaster. Herboso L, et al. Int J Dev Biol, 2011. PMID 21948708
    2. Effective but costly, evolved mechanisms of defense against a virulent opportunistic pathogen in Drosophila melanogaster. Ye YH, et al. PLoS Pathog, 2009 Apr. PMID 19381251, Free PMC Article
    3. Macrophage-derived upd3 cytokine causes impaired glucose homeostasis and reduced lifespan in Drosophila fed a lipid-rich diet. Woodcock KJ, et al. Immunity, 2015 Jan 20. PMID 25601202, Free PMC Article
    4. Systematic analysis of olfactory protein-protein interactions network of fruitfly, Drosophila melanogaster. Yang S, et al. Arch Insect Biochem Physiol, 2022 Jun. PMID 35249240
    5. The SNMP/CD36 gene family in Diptera, Hymenoptera and Coleoptera: Drosophila melanogaster, D. pseudoobscura, Anopheles gambiae, Aedes aegypti, Apis mellifera, and Tribolium castaneum. Nichols Z, et al. Insect Biochem Mol Biol, 2008 Apr. PMID 18342246

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables scavenger receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to protozoan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG10345-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      16597073..16604861 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142306.4 → NP_650563.2  uncharacterized protein Dmel_CG10345 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650563.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VET1, Q9Y121
      Related
      FBpp0082805
      Conserved Domains (1) summary
      pfam01130
      Location:21 → 488
      CD36; CD36 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VET1 Q9VET1
    Q9Y121 Q9Y121

    Gene LinkOut

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