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    lmd lame duck [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42717, updated on 17-Dec-2024

    Summary

    Official Symbol
    lmdprovided by FlyBase
    Official Full Name
    lame duckprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039039
    Locus tag
    Dmel_CG4677
    See related
    AllianceGenome:FB:FBgn0039039
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:CL2d4; CG4677; Dmel\CG4677; gfl; gfl.lmd; K; Lmd; LMD; minc
    Summary
    Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in several processes, including myoblast fusion; positive regulation of transcription by RNA polymerase II; and somatic muscle development. Located in cytosol and nucleus. Is expressed in several structures, including dorsal pharyngeal muscle primordium; fusion competent cell; larval somatic muscle cell; mesoderm; and visceral muscle primordium. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in neonatal diabetes mellitus with congenital hypothyroidism. Orthologous to human GLIS1 (GLIS family zinc finger 1) and GLIS3 (GLIS family zinc finger 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See lmd in Genome Data Viewer
    Location:
    94D9-94D10; 3-77 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23021222..23026713, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18846944..18852435, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44225 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44226

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    located_in cytosol PubMed 
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus  

    General protein information

    Preferred Names
    lame duck
    Names
    CG4677-PB
    CG4677-PC
    gleeful
    lameduck
    lmd-PB
    lmd-PC
    myoblasts incompetent

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      23021222..23026713 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170044.2 → NP_732811.1  lame duck, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732811.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K9G4, Q962I0
      Related
      FBpp0083757, FBtr0084364
      Conserved Domains (2) summary
      sd00017
      Location:504 → 526
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:489 → 515
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001275927.1 → NP_001262856.1  lame duck, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262856.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGM2, I1WYG9
      Conserved Domains (3) summary
      COG5048
      Location:6 → 55
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:6 → 25
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:17 → 44
      zf-H2C2_2; Zinc-finger double domain
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