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    RacGAP84C Rac GTPase activating protein at 84C [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 117503, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RacGAP84Cprovided by FlyBase
    Official Full Name
    Rac GTPase activating protein at 84Cprovided by FlyBase
    Primary source
    FLYBASE:FBgn0045843
    Locus tag
    Dmel_CG2595
    See related
    AllianceGenome:FB:FBgn0045843
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2595; Dmel\CG2595; GAP84C; P1.7; racGAP; RacGAP(84C); RhoGAP-84C8; rnGAP; rnprot; rnprot1.7; rnRac-GAP; rnracGap; rnracGAP; rnRacGap; rnRacGAP
    Summary
    Enables GTPase activator activity and small GTPase binding activity. Involved in Rho protein signal transduction; compound eye morphogenesis; and spermatogenesis. Predicted to be part of centralspindlin complex. Predicted to be active in several cellular components, including cleavage furrow; midbody; and spindle midzone. Is expressed in leg; ovary; spermatocyte; and testis. Human ortholog(s) of this gene implicated in congenital dyserythropoietic anemia. Orthologous to human RACGAP1 (Rac GTPase activating protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See RacGAP84C in Genome Data Viewer
    Location:
    84D3-84D3; 3-48 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7285962..7287629)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3111684..3113351)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene rotund Neighboring gene long non-coding RNA:CR44333 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44334

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Drosophila rotund transcript expressed during spermatogenesis and imaginal disc morphogenesis encodes a protein which is similar to human Rac GTPase-activating (racGAP) proteins. Agnel M, et al. Mol Cell Biol, 1992 Nov. PMID 1406685, Free PMC Article
    2. Alternative splicing of the Drosophila melanogaster rotundRacGAP gene. Hoemann CD, et al. Gene, 1996 Feb 12. PMID 8654933
    3. Overexpression of RnRacGAP in Drosophila melanogaster deregulates cytoskeletal organisation in cellularising embryos and induces discrete imaginal phenotypes. Guichard A, et al. Mech Dev, 1997 Jan. PMID 9076677
    4. RotundRacGAP functions with Ras during spermatogenesis and retinal differentiation in Drosophila melanogaster. Bergeret E, et al. Mol Cell Biol, 2001 Sep. PMID 11509670, Free PMC Article
    5. Two transcripts from the rotund region of Drosophila show similar positional specificities in imaginal disc tissues. Agnel M, et al. Genes Dev, 1989 Jan. PMID 2496007

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Rho protein signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in compound eye morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle midzone assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of centralspindlin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cleavage furrow IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in midbody IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in spindle midzone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Rac GTPase activating protein at 84C
    Names
    CG2595-PA
    CG2595-PB
    RacGAP84C-PA
    RacGAP84C-PB
    RnRacGAP
    RotundRACGAP
    rotund RacGAP

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      7285962..7287629
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057356.5 → NP_476704.1  Rac GTPase activating protein at 84C, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476704.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P40809, Q9VI91
      Related
      FBpp0081099
      Conserved Domains (2) summary
      cd04382
      Location:142 → 330
      RhoGAP_MgcRacGAP; RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin ...
      pfam00130
      Location:87 → 139
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    2. NM_057355.4 → NP_476703.1  Rac GTPase activating protein at 84C, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476703.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P40809
      Related
      FBpp0081100
      Conserved Domains (2) summary
      cd04382
      Location:142 → 330
      RhoGAP_MgcRacGAP; RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin ...
      pfam00130
      Location:87 → 139
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40809.1 P40809

    Gene LinkOut

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