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    ATPCL ATP citrate lyase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36760, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ATPCLprovided by FlyBase
    Official Full Name
    ATP citrate lyaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0020236
    Locus tag
    Dmel_CG8322
    See related
    AllianceGenome:FB:FBgn0020236
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ACL; Acly; anon-WO0140519.179; atpcl; Atpcl; BcDNA:LD21334; CG8322; CS; dATPCL; DmATPCL; Dmel\CG8322; l(2)01466; l(2)k09217; n(2)k09217
    Summary
    Predicted to enable ATP citrate synthase activity. Involved in acetyl-CoA biosynthetic process and glucose homeostasis. Predicted to be active in cytosol. Is expressed in adult head and adult heart. Orthologous to human ACLY (ATP citrate lyase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ATPCL in Genome Data Viewer
    Location:
    52D10-52D12; 2-76 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15993531..16001290, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11881036..11888795, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Peroxin 11a/b Neighboring gene uncharacterized protein Neighboring gene Transmembrane protein 131 Neighboring gene Ubiquitin-fold modifier conjugating enzyme 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila Citrate Lyase Is Required for Cell Division during Spermatogenesis. Di Giorgio ML, et al. Cells, 2020 Jan 14. PMID 31947614, Free PMC Article
    2. Life span extension by targeting a link between metabolism and histone acetylation in Drosophila. Peleg S, et al. EMBO Rep, 2016 Mar. PMID 26781291, Free PMC Article
    3. Depletion of ATP-Citrate Lyase (ATPCL) Affects Chromosome Integrity Without Altering Histone Acetylation in Drosophila Mitotic Cells. Morciano P, et al. Front Physiol, 2019. PMID 31019471, Free PMC Article
    4. The Organization of the Golgi Structures during Drosophila Male Meiosis Requires the Citrate Lyase ATPCL. Morciano P, et al. Int J Mol Sci, 2021 May 27. PMID 34072207, Free PMC Article
    5. Mio/dChREBP coordinately increases fat mass by regulating lipid synthesis and feeding behavior in Drosophila. Sassu ED, et al. Biochem Biophys Res Commun, 2012 Sep 14. PMID 22910416, Free PMC Article

    See all (87) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP citrate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP citrate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity, acyl groups converted into alkyl on transfer IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in acetyl-CoA biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in acetyl-CoA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in acetyl-CoA biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in citrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ATP citrate lyase
    Names
    ATP-citrate lyase
    ATPCL-PD
    ATPCL-PE
    ATPCL-PF
    ATPCL-PG
    CG8322-PD
    CG8322-PE
    CG8322-PF
    CG8322-PG
    NP_001137674.2
    NP_001286470.1
    NP_523755.2
    NP_725514.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      15993531..16001290 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001144202.3 → NP_001137674.2  ATP citrate lyase, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137674.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZA78, B7YZH5, Q6AWP8, Q7KN85
      Conserved Domains (7) summary
      cd06100
      Location:868 → 1105
      CCL_ACL-C; Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA). ...
      PLN02235
      Location:1 → 421
      PLN02235; ATP citrate (pro-S)-lyase
      PLN02522
      Location:503 → 1106
      PLN02522; ATP citrate (pro-S)-lyase
      smart00881
      Location:504 → 613
      CoA_binding; CoA binding domain
      pfam16114
      Location:248 → 423
      Citrate_bind; ATP citrate lyase citrate-binding
      cl17255
      Location:8 → 208
      ATP-grasp_4; ATP-grasp domain
      cl22543
      Location:672 → 796
      Ligase_CoA; CoA-ligase

    2. NM_079031.3 → NP_523755.2  ATP citrate lyase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523755.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZA78, B7YZH5, Q6AWP8, Q7KN85
      Conserved Domains (7) summary
      cd06100
      Location:868 → 1105
      CCL_ACL-C; Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA). ...
      PLN02235
      Location:1 → 421
      PLN02235; ATP citrate (pro-S)-lyase
      PLN02522
      Location:503 → 1106
      PLN02522; ATP citrate (pro-S)-lyase
      smart00881
      Location:504 → 613
      CoA_binding; CoA binding domain
      pfam16114
      Location:248 → 423
      Citrate_bind; ATP citrate lyase citrate-binding
      cl17255
      Location:8 → 208
      ATP-grasp_4; ATP-grasp domain
      cl22543
      Location:672 → 796
      Ligase_CoA; CoA-ligase

    3. NM_166131.3 → NP_725514.2  ATP citrate lyase, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725514.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E2QCF1, Q6AWP8
      Conserved Domains (7) summary
      cd06100
      Location:851 → 1088
      CCL_ACL-C; Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA). ...
      PLN02235
      Location:1 → 421
      PLN02235; ATP citrate (pro-S)-lyase
      PLN02522
      Location:486 → 1089
      PLN02522; ATP citrate (pro-S)-lyase
      smart00881
      Location:487 → 596
      CoA_binding; CoA binding domain
      pfam16114
      Location:248 → 423
      Citrate_bind; ATP citrate lyase citrate-binding
      cl17255
      Location:8 → 208
      ATP-grasp_4; ATP-grasp domain
      cl22543
      Location:655 → 779
      Ligase_CoA; CoA-ligase

    4. NM_001299541.1 → NP_001286470.1  ATP citrate lyase, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286470.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LFH8, Q6AWP8
      Conserved Domains (7) summary
      cd06100
      Location:852 → 1089
      CCL_ACL-C; Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA). ...
      PLN02235
      Location:1 → 421
      PLN02235; ATP citrate (pro-S)-lyase
      PLN02522
      Location:487 → 1090
      PLN02522; ATP citrate (pro-S)-lyase
      smart00881
      Location:488 → 597
      CoA_binding; CoA binding domain
      pfam16114
      Location:248 → 423
      Citrate_bind; ATP citrate lyase citrate-binding
      cl17255
      Location:8 → 208
      ATP-grasp_4; ATP-grasp domain
      cl22543
      Location:656 → 780
      Ligase_CoA; CoA-ligase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LFH8 A0A0B4LFH8
    E2QCF1 E2QCF1
    Q6NR74 Q6NR74
    Q7JNC6 Q7JNC6
    Q7KN85 Q7KN85

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