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    sca scabrous [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36411, updated on 17-Dec-2024

    Summary

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    Official Symbol
    scaprovided by FlyBase
    Official Full Name
    scabrousprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003326
    Locus tag
    Dmel_CG17579
    See related
    AllianceGenome:FB:FBgn0003326
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AAA28880; AAF58455; anon-EST:Liang-38; CG17579; clone 38; Dmel\CG17579; FBpp0086968; FBpp0086969; mAb sca1; Sca; Sca1b
    Summary
    Involved in several processes, including chaeta morphogenesis; imaginal disc-derived wing margin morphogenesis; and ommatidial rotation. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in several structures, including epithelial cell; epithelium; ganglia; imaginal disc; and somatic precursor cell. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; brain ischemia; diabetic retinopathy; familial hypobetalipoproteinemia 2; and hereditary angioedema. Orthologous to several human genes including ANGPT1 (angiopoietin 1); ANGPT2 (angiopoietin 2); and ANGPT4 (angiopoietin 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See sca in Genome Data Viewer
    Location:
    49C3-49D3; 2-67 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12780541..12802010)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8668046..8689515)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45266 Neighboring gene antisense RNA:CR45137 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44453

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Quantitative genetics. Loci with large effects. Keightley PD. Curr Biol, 1995 May 1. PMID 7583095
    2. Linkage disequilibrium mapping of molecular polymorphisms at the scabrous locus associated with naturally occurring variation in bristle number in Drosophila melanogaster. Lyman RF, et al. Genet Res, 1999 Dec. PMID 10689806
    3. Naturally occurring variation in bristle number and DNA polymorphisms at the scabrous locus of Drosophila melanogaster. Lai C, et al. Science, 1994 Dec 9. PMID 7992053
    4. Scabrous is distributed via signaling filopodia to modulate Notch response during bristle patterning in Drosophila. Presser A, et al. PLoS One, 2023. PMID 37729137, Free PMC Article
    5. Functional analysis of the fibrinogen-related scabrous gene from Drosophila melanogaster identifies potential effector and stimulatory protein domains. Lee EC, et al. Genetics, 1998 Oct. PMID 9755198, Free PMC Article

    See all (271) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Scabrous is distributed via signaling filopodia to modulate Notch response during bristle patterning in Drosophila.
      Title: Scabrous is distributed via signaling filopodia to modulate Notch response during bristle patterning in Drosophila.
    2. Study shows that Drosophila Notch/Su(H) signaling and the secreted fibrinogen-related protein Scabrous in mushroom body memory circuitry are important for the enduring preference of cues associated with alcohol's rewarding properties.
      Title: Alcohol Activates Scabrous-Notch to Influence Associated Memories.
    3. These and other results obtained with a reporter line of Notch activity indicate that sca overexpression antagonizes Notch signaling in the Drosophila eye, and are inconsistent with Sca being an ommatidial rotation-specific factor.
      Title: Scabrous overexpression in the eye affects R3/R4 cell fate specification and inhibits notch signaling.
    4. Scabrous is an activator that can overcome the sensitivity of template-based lateral inhibition to spatial variations in biochemical parameters and cell sizes in eye development.
      Title: Periodic patterning of the Drosophila eye is stabilized by the diffusible activator Scabrous.
    5. Data suggest that endosomal Scabrous and Gp150 promote Notch activation in response to Delta, by regulating acquisition of insensitivity to Delta in a subset of cells.
      Title: Scabrous and Gp150 are endosomal proteins that regulate Notch activity.
    6. Notch, Delta, and Scabrous might function in complex combinatorial or mutually exclusive interactions during Drosophila development.
      Title: Delta activity independent of its activity as a ligand of Notch.
    7. Scabrous controls the stop of ommatidial rotation by suppressing nemo activity in the second 45 degrees rotation. The morphogenetic furrow regulates precise ommatidial rotation by transporting Scabrous through actin-based cellular extensions.
      Title: Scabrous controls ommatidial rotation in the Drosophila compound eye.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in chaeta morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in compound eye development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in compound eye development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing margin morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nervous system development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ommatidial rotation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to alcohol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    scabrous
    Names
    CG17579-PA
    CG17579-PB
    Fibrinogen-related protein
    sca-PA
    sca-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12780541..12802010
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165951.2 → NP_725230.2  scabrous, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725230.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P21520, Q0E998, Q8MQI8, Q9V6G9
      Related
      FBpp0086969
      Conserved Domains (2) summary
      smart00186
      Location:538 → 736
      FBG; Fibrinogen-related domains (FReDs)
      cl21524
      Location:200 → 300
      PRK13923; putative spore coat protein regulator protein YlbO; Provisional

    2. NM_057362.3 → NP_476710.2  scabrous, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476710.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P21520, Q0E998, Q8MQI8, Q9V6G9
      Related
      FBpp0086968
      Conserved Domains (2) summary
      smart00186
      Location:538 → 736
      FBG; Fibrinogen-related domains (FReDs)
      cl21524
      Location:200 → 300
      PRK13923; putative spore coat protein regulator protein YlbO; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P21520.3 P21520

    Gene LinkOut

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