Strip Striatin interacting protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Stripprovided by FlyBase
Official Full Name: Striatin interacting proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0035437
Locus tag: Dmel_CG11526
See related: AllianceGenome:FB:FBgn0035437
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG11526; Dmel\CG11526; strip
Summary: Enables protein kinase binding activity. Involved in several processes, including axon extension; negative regulation of signal transduction; and negative regulation of synaptic assembly at neuromuscular junction. Located in cytoplasm and presynapse. Part of FAR/SIN/STRIPAK complex. Is expressed in embryonic/larval neuromuscular junction. Orthologous to human STRIP1 (striatin interacting protein 1) and STRIP2 (striatin interacting protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (3322025..3328871, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (3322025..3328871, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

A novel role for Strip/Cka in JNK pathway regulation during spermatogenesis within the developing Drosophila testis.
Title: Strip and Cka negatively regulate JNK signalling during Drosophila spermatogenesis.
The study identifies a previously unanticipated role of the Strip-Hippo pathway in synaptic development, linking cell signaling to actin organization.
Title: The Strip-Hippo Pathway Regulates Synaptic Terminal Formation by Modulating Actin Organization at the Drosophila Neuromuscular Synapses.
Strip is a key regulator for neuronal morphogenesis.
Title: Drosophila Strip serves as a platform for early endosome organization during axon elongation.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in endosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of JNK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of hippo signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of hippo signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of tumor necrosis factor-mediated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of Ras protein signal transduction	HGI more info	PubMed

Component	Evidence Code	Pubs
part_of FAR/SIN/STRIPAK complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in presynapse	IDA Inferred from Direct Assay more info	PubMed

Names: CG11526-PA; CG11526-PB; CG11526-PC; Strip-PA; Strip-PB; Strip-PC; striatin interacting protein ortholog

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The following sections contain reference sequences that belong to a specific genome build. Explain