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    MtnD Metallothionein D [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 326270, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MtnDprovided by FlyBase
    Official Full Name
    Metallothionein Dprovided by FlyBase
    Primary source
    FLYBASE:FBgn0053192
    Locus tag
    Dmel_CG33192
    See related
    AllianceGenome:FB:FBgn0053192
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG33192; Dmel\CG33192; MT; mtnD; MTND
    Summary
    Enables metal ion binding activity. Involved in cellular detoxification of metal ion and response to copper ion. Is expressed in embryonic/larval copper cell; embryonic/larval midgut; and larval iron accumulating cell. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See MtnD in Genome Data Viewer
    Location:
    92F1-92F1; 3-69 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (20534962..20535301)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16360684..16361023)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Major Facilitator Superfamily Transporter 9 Neighboring gene Signal-transducer and activator of transcription protein at 92E Neighboring gene Metallothionein E Neighboring gene alternative testis transcripts open reading frame B Neighboring gene Dephosphocoenzyme A carrier

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila bloom helicase maintains genome integrity by inhibiting recombination between divergent DNA sequences. Kappeler M, et al. Nucleic Acids Res, 2008 Dec. PMID 18978019, Free PMC Article
    2. Is MtnE, the fifth Drosophila metallothionein, functionally distinct from the other members of this polymorphic protein family? Pérez-Rafael S, et al. Metallomics, 2012 Apr. PMID 22370740
    3. An Indel Polymorphism in the MtnA 3' Untranslated Region Is Associated with Gene Expression Variation and Local Adaptation in Drosophila melanogaster. Catalán A, et al. PLoS Genet, 2016 Apr. PMID 27120580, Free PMC Article
    4. Metallothioneins and resistance to cadmium poisoning in Drosophila cells. Debec A, et al. Biochem Biophys Res Commun, 1985 Feb 28. PMID 3919723
    5. Knockout of 'metal-responsive transcription factor' MTF-1 in Drosophila by homologous recombination reveals its central role in heavy metal homeostasis. Egli D, et al. EMBO J, 2003 Jan 2. PMID 12505988, Free PMC Article

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metal ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular detoxification of metal ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to copper ion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to metal ion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to metal ion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    metallothionein D
    Names
    CG33192-PB
    MtnD-PB
    metallothionein
    NP_788695.2
    • point mutation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      20534962..20535301
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_176518.2 → NP_788695.2  metallothionein D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788695.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q1WW94, Q86B88, Q8I9B4
      Conserved Domains (1) summary
      pfam02067
      Location:1 → 41
      Metallothio_5; Metallothionein family 5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8I9B4.1 Q8I9B4

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