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    nullo nullo [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31652, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nulloprovided by FlyBase
    Official Full Name
    nulloprovided by FlyBase
    Primary source
    FLYBASE:FBgn0004143
    Locus tag
    Dmel_CG14426
    See related
    AllianceGenome:FB:FBgn0004143
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE47733; CG14426; Dmel\CG14426; Nullo
    Summary
    Involved in several processes, including cell-cell junction assembly; cleavage furrow formation; and regulation of cell shape. Predicted to be located in adherens junction. Is expressed in ectoderm; epithelial cell; epithelium; and organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See nullo in Genome Data Viewer
    Location:
    6F1-6F1; 1-19 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (7049476..7050321)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6943509..6944354)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Sex lethal Neighboring gene mir-4956 stem loop

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The nullo protein is a component of the actin-myosin network that mediates cellularization in Drosophila melanogaster embryos. Postner MA, et al. J Cell Sci, 1994 Jul. PMID 7983153
    2. A transgenic female killing system for the genetic control of Drosophila suzukii. Schetelig MF, et al. Sci Rep, 2021 Jun 21. PMID 34155227, Free PMC Article
    3. Actin cytoskeleton. Through the bottleneck. Theurkauf WE. Curr Biol, 1994 Jan 1. PMID 7922320
    4. Identification and characterization of four Drosophila suzukii cellularization genes and their promoters. Yan Y, et al. BMC Genet, 2020 Dec 18. PMID 33339500, Free PMC Article
    5. Conserved domains of the Nullo protein required for cell-surface localization and formation of adherens junctions. Hunter C, et al. Mol Biol Cell, 2002 Jan. PMID 11809829, Free PMC Article

    See all (92) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We propose that Nullo compartmentalizes furrows via its regulation of F-actin, thus stabilizing furrows and insuring their ingression to complete cellularization.
      Title: Zygotically controlled F-actin establishes cortical compartments to stabilize furrows during Drosophila cellularization.
    2. Conserved domains of Nullo protein is required for cell-surface localization and formation of adherens junctions in Drosophila.
      Title: Conserved domains of the Nullo protein required for cell-surface localization and formation of adherens junctions.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in cell-cell junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellularization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cleavage furrow formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in morphogenesis of embryonic epithelium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in adherens junction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cell-cell junction TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nullo
    Names
    CG14426-PB
    nullo-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      7049476..7050321
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078512.5 → NP_511067.3  nullo [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_511067.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P32845, Q9W3S9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32845.4 P32845

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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