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    PAH2 phosphatidic acid phosphohydrolase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834298, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PAH2
    Official Full Name
    phosphatidic acid phosphohydrolase 2
    Primary source
    TAIR:AT5G42870
    Locus tag
    AT5G42870
    See related
    Araport:AT5G42870
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATPAH2; MBD2.6; MBD2_6; phosphatidic acid phosphohydrolase 2; PHOSPHATIDIC ACID PHOSPHOHYDROLASE 2
    Summary
    The PAH2 gene encodes a phosphatidate phosphohydrolase. Mutant analysis revealed its involvement in galactolipid synthesis pathway, and the membrane lipid remodeling. The pah1pah2 double-mutant showed enhanced Al-susceptibility under low-P conditions, but there was no significant differences in Al tolerance between pah1pah2 and wild type when they were grown in a solution containing 35 muM Pi.
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    Genomic context

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    See PAH2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    11
    Sequence:
    Chromosome: 5; NC_003076.8 (17185440..17189978, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Thioredoxin superfamily protein Neighboring gene late embryogenesis abundant protein, group 2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene WEAK CHLOROPLAST MOVEMENT UNDER BLUE LIGHT-like protein (DUF827)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phosphatidic acid phosphohydrolase 1 and 2 regulate phospholipid synthesis at the endoplasmic reticulum in Arabidopsis. Eastmond PJ, et al. Plant Cell, 2010 Aug. PMID 20699392, Free PMC Article
    2. Arabidopsis lipins mediate eukaryotic pathway of lipid metabolism and cope critically with phosphate starvation. Nakamura Y, et al. Proc Natl Acad Sci U S A, 2009 Dec 8. PMID 19923426, Free PMC Article
    3. Cyclin-dependent kinase activity enhances phosphatidylcholine biosynthesis in Arabidopsis by repressing phosphatidic acid phosphohydrolase activity. Craddock CP, et al. Plant J, 2017 Jan. PMID 27595588, Free PMC Article
    4. Deciphering the roles of Arabidopsis LPCAT and PAH in phosphatidylcholine homeostasis and pathway coordination for chloroplast lipid synthesis. Wang L, et al. Plant J, 2014 Dec. PMID 25268378
    5. Hydroponic isotope labelling of entire plants (HILEP) for quantitative plant proteomics; an oxidative stress case study. Bindschedler LV, et al. Phytochemistry, 2008 Jul. PMID 18538804

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that phosphatidylcholine (PC) biosynthesis is repressed by disruption of the core cell cycle regulator CYCLIN-DEPENDENT KINASE A;1 (CDKA;1) and that this repression is reliant on PHOSPHATIDIC ACID PHOSPHOHYDROLASE (PAH).
      Title: Cyclin-dependent kinase activity enhances phosphatidylcholine biosynthesis in Arabidopsis by repressing phosphatidic acid phosphohydrolase activity.
    2. PAH1 and PAH2 function indirectly as repressors of phospholipid biosynthesis.
      Title: Phosphatidic acid phosphohydrolase 1 and 2 regulate phospholipid synthesis at the endoplasmic reticulum in Arabidopsis.
    Submit: New GeneRIF Correction

    General gene information

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    NM_001203528.2
    NM_001344465.1
    NM_123652.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables phosphatidate phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidate phosphatase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to phosphate starvation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within galactolipid biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within lipid metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within phospholipid biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apoplast HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidic acid phosphohydrolase 2
    NP_001190457.1
    • phosphatidic acid phosphohydrolase 2 (PAH2); FUNCTIONS IN: phosphatidate phosphatase activity; INVOLVED IN: cellular response to phosphate starvation, lipid metabolic process; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: LNS2, Lipin/Ned1/Smp2 (InterPro:IPR013209), Lipin, N-terminal conserved region (InterPro:IPR007651); BEST Arabidopsis thaliana protein match is: Lipin family protein (TAIR:AT3G09560.3).
    NP_199101.1
    • phosphatidic acid phosphohydrolase 2 (PAH2); FUNCTIONS IN: phosphatidate phosphatase activity; INVOLVED IN: cellular response to phosphate starvation, lipid metabolic process; LOCATED IN: apoplast, membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: LNS2, Lipin/Ned1/Smp2 (InterPro:IPR013209), Lipin, N-terminal conserved region (InterPro:IPR007651); BEST Arabidopsis thaliana protein match is: Lipin family protein (TAIR:AT3G09560.3); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      17185440..17189978 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001203528.2 → NP_001190457.1  phosphatidic acid phosphohydrolase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190457.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UHU4, F4K347
      Conserved Domains (3) summary
      pfam04571
      Location:1 → 93
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:682 → 901
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:540 → 640
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    2. NM_123652.3 → NP_199101.1  phosphatidic acid phosphohydrolase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199101.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D8L211, Q9FMN2
      UniProtKB/TrEMBL
      A0A654G7J2
      Conserved Domains (3) summary
      pfam04571
      Location:1 → 93
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:682 → 906
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:540 → 640
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    3. NM_001344465.1 → NP_001330498.1  phosphatidic acid phosphohydrolase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BB14, A0A654G7J2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FMN2.1

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