miple1 midkine and pleiotrophin 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: miple1provided by FlyBase
Official Full Name: midkine and pleiotrophin 1provided by FlyBase
Primary source: FLYBASE:FBgn0027111
Locus tag: Dmel_CG1221
See related: AllianceGenome:FB:FBgn0027111
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-EST:Posey203; CG1221; Dmel\CG1221; miple; Miple
Summary: Enables heparin binding activity. Involved in determination of adult lifespan and mesoderm morphogenesis. Located in extracellular region. Is expressed in several structures, including embryonic ventral epidermis; embryonic/larval anterior midgut; ganglia; imaginal disc; and trunk visceral muscle primordium. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (267299..270336)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (267299..270336)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

The data suggest that Alk is not activated by MDK/PTN related growth factors Miple1 and Miple2 in vivo.
Title: The Drosophila midkine/pleiotrophin homologues Miple1 and Miple2 affect adult lifespan but are dispensable for alk signaling during embryonic gut formation.
One of the roles of Nmo during ommatial rotation is to repress miple expression, which may in turn affect the dynamics in E-cadherin-beta-catenin complexes.
Title: Nemo regulates cell dynamics and represses the expression of miple, a midkine/pleiotrophin cytokine, during ommatidial rotation.
overexpression of miple (a midkine and pleiotrophin heparin-binding growth factor), in the mesoderm led to abnormal scattered MAPK activation, a phenotype that might explain the abnormal mesoderm spreading
Title: Post-transcriptional repression of the Drosophila midkine and pleiotrophin homolog miple by HOW is essential for correct mesoderm spreading.
Expression can be found at high levels in the central nervous system.
Title: Miple1 and miple2 encode a family of MK/PTN homologues in Drosophila melanogaster.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables heparin binding	IBA Inferred from Biological aspect of Ancestor more info
enables heparin binding	IDA Inferred from Direct Assay more info	PubMed
enables heparin binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesoderm morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in mesoderm morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed

Names: CG1221-PA; CG1221-PB; CG1221-PC; miple; miple1-PA; miple1-PB; miple1-PC

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The following sections contain reference sequences that belong to a specific genome build. Explain