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    Usf Usf [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31384, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Usfprovided by FlyBase
    Official Full Name
    Usfprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029711
    Locus tag
    Dmel_CG17592
    See related
    AllianceGenome:FB:FBgn0029711
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    bHLHb13; CG17592; Dm Usf; Dmel\CG17592; DmUsf; dUSF; dUSF2
    Summary
    Enables E-box binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Is expressed in several structures, including embryonic/larval garland cell; garland cell primordium; head mesoderm; and spermatocyte. Human ortholog(s) of this gene implicated in cardiovascular system disease and type 2 diabetes mellitus. Orthologous to human USF1 (upstream transcription factor 1) and USF2 (upstream transcription factor 2, c-fos interacting). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Usf in Genome Data Viewer
    Location:
    4C7-4C7; 1-8 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (4544617..4548794, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (4438650..4442827, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR32773 Neighboring gene CHOp24 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolutionary divergence of Threonine Aspartase1 leads to species-specific substrate recognition. Wünsch D, et al. Biol Chem, 2015 Apr. PMID 25720119
    2. Promoter contribution to the testis-specific expression of Stellate gene family in Drosophila melanogaster. Olenkina OM, et al. Gene, 2012 May 10. PMID 22425977
    3. A genomewide survey of basic helix-loop-helix factors in Drosophila. Moore AW, et al. Proc Natl Acad Sci U S A, 2000 Sep 12. PMID 10973473, Free PMC Article
    4. New members of the Drosophila Myc transcription factor subfamily revealed by a genome-wide examination for basic helix-loop-helix genes. Peyrefitte S, et al. Mech Dev, 2001 Jun. PMID 11404084
    5. The basic helix-loop-helix protein family: comparative genomics and phylogenetic analysis. Ledent V, et al. Genome Res, 2001 May. PMID 11337472, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables E-box binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Usf
    Names
    CG17592-PB
    CG17592-PC
    Usf-PB
    Usf-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      4544617..4548794 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167010.3 → NP_726931.2  Usf, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726931.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W4J8
      Conserved Domains (1) summary
      pfam00010
      Location:255 → 343
      HLH; Helix-loop-helix DNA-binding domain

    2. NM_131939.6 → NP_572167.3  Usf, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572167.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W4J8
      Related
      FBpp0070669
      Conserved Domains (1) summary
      pfam00010
      Location:255 → 343
      HLH; Helix-loop-helix DNA-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JQK3 Q7JQK3
    Q9W4J8 Q9W4J8

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