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    Ser8 Ser8 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36489, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ser8provided by FlyBase
    Official Full Name
    Ser8provided by FlyBase
    Primary source
    FLYBASE:FBgn0019928
    Locus tag
    Dmel_CG4812
    See related
    AllianceGenome:FB:FBgn0019928
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4812; Dmel\CG4812; SP#3; SP3; SP90
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Orthologous to human PRSS36 (serine protease 36) and PRSS53 (serine protease 53). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ser8 in Genome Data Viewer
    Location:
    50A8-50A8; 2-68 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13434207..13435045)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9321712..9322550)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene ATPase 8A Neighboring gene transfer RNA:Leucine-CAA 1-1 Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Isoleucine-AAT 1-8 Neighboring gene centrosomin Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Induction of a putative serine protease transcript in immune challenged Drosophila. Coustau C, et al. Dev Comp Immunol, 1996 Jul-Aug. PMID 8915628
    2. Infection-induced host translational blockage inhibits immune responses and epithelial renewal in the Drosophila gut. Chakrabarti S, et al. Cell Host Microbe, 2012 Jul 19. PMID 22817988
    3. A genome-wide analysis of courting and mating responses in Drosophila melanogaster females. Lawniczak MK, et al. Genome, 2004 Oct. PMID 15499404
    4. First transcriptome profiling of D. melanogaster after development in a deep underground low radiation background laboratory. Zarubin M, et al. PLoS One, 2021. PMID 34351964, Free PMC Article
    5. Damage sensing mediated by serine proteases Hayan and Persephone for Toll pathway activation in apoptosis-deficient flies. Nakano S, et al. PLoS Genet, 2023 Jun. PMID 37319131, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables serine-type peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ser8
    Names
    CG4812-PA
    Ser8-PA
    serine protease 3
    NP_610874.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      13434207..13435045
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137030.3 → NP_610874.1  Ser8 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610874.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0JQ46, Q4V3S6
      Related
      FBpp0086785
      Conserved Domains (2) summary
      smart00020
      Location:34 → 253
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:35 → 253
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4V3S6 Q4V3S6

    Gene LinkOut

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