tsh teashirt [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: tshprovided by FlyBase
Official Full Name: teashirtprovided by FlyBase
Primary source: FLYBASE:FBgn0003866
Locus tag: Dmel_CG1374
See related: AllianceGenome:FB:FBgn0003866
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: ae; ae[l]; CG1374; Dmel\CG1374; l(2)04319; l(2)B4-2-12; T shirt; Tsh; TSH
Summary: Enables DNA binding activity and DNA-binding transcription repressor activity, RNA polymerase II-specific. Involved in several processes, including Malpighian tubule stellate cell differentiation; regionalization; and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including Malpighian tubule Type II cell; anterior-posterior subdivision of organism; epithelium; gut section; and imaginal disc. Orthologous to human TSHZ1 (teashirt zinc finger homeobox 1); TSHZ2 (teashirt zinc finger homeobox 2); and TSHZ3 (teashirt zinc finger homeobox 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 40A5-40A5; 2-54 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (21828593..21837011)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (21828593..21837011)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Baf-mediated transcriptional regulation of teashirt is essential for the development of neural progenitor cell lineages.
Title: Baf-mediated transcriptional regulation of teashirt is essential for the development of neural progenitor cell lineages.
Rather than directly regulating cell cycle genes, hth and tsh control cell proliferation through an intermediary layer of nuclear receptors of the ecdysone/estrogen-signaling pathway.
Title: Nuclear receptors connect progenitor transcription factors to cell cycle control.
Hth+Tsh-induced tissue overgrowth requires the BMP2 Dpp and the abnormal hyperactivation of its pathway. Rather than using autocrine Dpp expression, Hth+Tsh cells increase their avidity for Dpp, produced locally, by upregulating extracellular matrix components.
Title: Increased avidity for Dpp/BMP2 maintains the proliferation of progenitors-like cells in the Drosophila eye.
studies demonstrate a novel neuroprotective function of tsh and its paralog tio in Abeta42 mediated neurodegeneration
Title: Homeotic Gene teashirt (tsh) has a neuroprotective function in amyloid-beta 42 mediated neurodegeneration.
Tiptop/teashirt genes regulate cell differentiation and renal physiology in Drosophila.
Title: The tiptop/teashirt genes regulate cell differentiation and renal physiology in Drosophila.
Tsh contains three zinc finger motifs the second zinc finger is essential to the proper functioning of the protein while the remaining zinc finger domains appear to contribute but are not absolutely required
Title: A dissection of the teashirt and tiptop genes reveals a novel mechanism for regulating transcription factor activity.
Data demonstrate that ectopic eye formation by teashirt and its paralog tiptop, a potential new eye specification gene, is restricted to the developing antennae.
Title: Restriction of ectopic eye formation by Drosophila teashirt and tiptop to the developing antenna.
Data show that tio (tiptop) and tsh (teashirt) have coincident expression domains in the imaginal discs, the precursors of the adult body, and that both genes show similar functional properties when expressed ectopically.
Title: Zinc-finger paralogues tsh and tio are functionally equivalent during imaginal development in Drosophila and maintain their expression levels through auto- and cross-negative feedback loops.
Eye suppression, a novel function of this protein, requires Wingless signaling
Title: Eye suppression, a novel function of teashirt, requires Wingless signaling.
promotes eye development in dorsal and suppressing eye development in ventral by Wingless mediated Homothorax (HTH) induction
Title: Dorso-ventral asymmetric functions of teashirt in Drosophila eye development depend on spatial cues provided by early DV patterning genes.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0627 (e-PCR)
- UniSTS:74814

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Malpighian tubule stellate cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in Malpighian tubule stellate cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Wnt signaling pathway	IPI Inferred from Physical Interaction more info	PubMed
involved_in compound eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal/ventral pattern formation, imaginal disc	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epidermis morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eye-antennal disc development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in head involution	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in leg disc proximal/distal pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in midgut development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of salivary gland boundary specification	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell proliferation involved in compound eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in specification of segmental identity, head	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in specification of segmental identity, thorax	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in specification of segmental identity, trunk	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc proximal/distal pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: teashirt

Names: CG1374-PA; T-shirt; aeroplane; tsh-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

21828593..21837011

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078891.3 → NP_523615.2 teashirt [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523615.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A8E6H0, P22265, Q6AWP7, Q7KRS3, Q9V9Q0

Related

FBpp0085261

Conserved Domains (2) summary

sd00020
Location:356 → 378

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam12756
Location:354 → 382

zf-C2H2_2; C2H2 type zinc-finger (2 copies)