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    CAC1 chloroplastic acetylcoenzyme A carboxylase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831500, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CAC1
    Official Full Name
    chloroplastic acetylcoenzyme A carboxylase 1
    Primary source
    TAIR:AT5G16390
    Locus tag
    AT5G16390
    See related
    Araport:AT5G16390
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    BCCP; BCCP-1; BCCP1; BIOTIN CARBOXYL CARRIER PROTEIN; BIOTIN CARBOXYL-CARRIER PROTEIN; BIOTIN CARBOXYL-CARRIER PROTEIN 1; CAC1-A; CAC1A; chloroplastic acetylcoenzyme A carboxylase 1; MQK4.12; MQK4_12
    Summary
    Encodes for the biotin carboxyl-carrier subunit of the multi-enzyme plastidial acetyl-coenzyme A carboxylase complex.
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    Genomic context

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    See CAC1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    7
    Sequence:
    Chromosome: 5; NC_003076.8 (5360789..5363297, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene tRNA-Ser Neighboring gene autophagy-like protein, putative (Protein of unknown function, DUF538) Neighboring gene thioredoxin F2 Neighboring gene HXXXD-type acyl-transferase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of the cDNA coding for the biotin-containing subunit of the chloroplastic acetyl-coenzyme A carboxylase. Choi JK, et al. Plant Physiol, 1995 Oct. PMID 7480350, Free PMC Article
    2. Reverse-genetic analysis of the two biotin-containing subunit genes of the heteromeric acetyl-coenzyme A carboxylase in Arabidopsis indicates a unidirectional functional redundancy. Li X, et al. Plant Physiol, 2011 Jan. PMID 21030508, Free PMC Article
    3. Brassicaceae express multiple isoforms of biotin carboxyl carrier protein in a tissue-specific manner. Thelen JJ, et al. Plant Physiol, 2001 Apr. PMID 11299381, Free PMC Article
    4. 14-3-3 proteins fine-tune plant nutrient metabolism. Shin R, et al. FEBS Lett, 2011 Jan 3. PMID 21094157
    5. AT_CHLORO, a comprehensive chloroplast proteome database with subplastidial localization and curated information on envelope proteins. Ferro M, et al. Mol Cell Proteomics, 2010 Jun. PMID 20061580, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. BCCP1 protein can compensate for the lack of BCCP2, the absence of BCCP1 cannot be tolerated as BCCP2 levels are not sufficient to support heteromeric acetyl-coenzyme A carboxylase activity at a level that is required for normal growth and development.
      Title: Reverse-genetic analysis of the two biotin-containing subunit genes of the heteromeric acetyl-coenzyme A carboxylase in Arabidopsis indicates a unidirectional functional redundancy.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_121644.4
    NM_203060.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables acetyl-CoA carboxylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acetyl-CoA carboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables biotin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within fatty acid biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of acetyl-CoA carboxylase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chloroplast HDA PubMed 
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast stroma HDA PubMed 
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    chloroplastic acetylcoenzyme A carboxylase 1
    NP_197143.1
    • chloroplastic acetylcoenzyme A carboxylase 1 (CAC1); FUNCTIONS IN: acetyl-CoA carboxylase activity, biotin binding; INVOLVED IN: fatty acid biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Biotin-binding site (InterPro:IPR001882), Single hybrid motif (InterPro:IPR011053), Acetyl-CoA biotin carboxyl carrier (InterPro:IPR001249), Biotin/lipoyl attachment (InterPro:IPR000089); BEST Arabidopsis thaliana protein match is: biotin carboxyl carrier protein 2 (TAIR:AT5G15530.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).
    NP_974789.1
    • BIOTIN CARBOXYL-CARRIER PROTEIN 1 (BCCP-1); FUNCTIONS IN: acetyl-CoA carboxylase activity, biotin binding; INVOLVED IN: fatty acid biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Acetyl-CoA biotin carboxyl carrier (InterPro:IPR001249), Single hybrid motif (InterPro:IPR011053), Biotin/lipoyl attachment (InterPro:IPR000089); BEST Arabidopsis thaliana protein match is: biotin carboxyl carrier protein 2 (TAIR:AT5G15530.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      5360789..5363297 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121644.4 → NP_197143.1  chloroplastic acetylcoenzyme A carboxylase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197143.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04845, Q42533, Q9LL78
      UniProtKB/TrEMBL
      A0A178ULU5, A0A5S9Y5B4
      Conserved Domains (1) summary
      PLN02983
      Location:1 → 280
      PLN02983; biotin carboxyl carrier protein of acetyl-CoA carboxylase

    2. NM_203060.2 → NP_974789.1  chloroplastic acetylcoenzyme A carboxylase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974789.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178ULR4, F4KE21
      Conserved Domains (2) summary
      PLN02983
      Location:1 → 251
      PLN02983; biotin carboxyl carrier protein of acetyl-CoA carboxylase
      pfam00364
      Location:205 → 251
      Biotin_lipoyl; Biotin-requiring enzyme
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q42533.2

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