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    Usp47 Ubiquitin specific protease 47 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38644, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Usp47provided by FlyBase
    Official Full Name
    Ubiquitin specific protease 47provided by FlyBase
    Primary source
    FLYBASE:FBgn0016756
    Locus tag
    Dmel_CG5486
    See related
    AllianceGenome:FB:FBgn0016756
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LD12764; CG5486; D-Ubp-64E; D-UBP-64E; Dmel\CG5486; dUbp64; dUBP64; dUSP47; E(var)1; E(var)3-64E; E-var(3)64E; Q24574; UBP; ubp64; Ubp64; ubp64E; Ubp64E; UBP64E; Upd64E; usp47; USP47
    Summary
    Enables cysteine-type deubiquitinase activity. Involved in several processes, including negative regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of signal transduction; and protein stabilization. Located in cytosol and nucleus. Is expressed in several structures, including cuboidal/columnar epithelium; larval central nervous system; larval muscle cell; and larval muscle system. Orthologous to human USP47 (ubiquitin specific peptidase 47). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Usp47 in Genome Data Viewer
    Location:
    64E5-64E6; 3-15 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (5752973..5761886)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (5746073..5754986)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene still life Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene DnaJ-like-1 Neighboring gene ncRNA Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Deubiquitinating enzymes: their diversity and emerging roles. Chung CH, et al. Biochem Biophys Res Commun, 1999 Dec 29. PMID 10603300
    2. DNAJB4 molecular chaperone distinguishes WT from mutant E-cadherin, determining their fate in vitro and in vivo. Simões-Correia J, et al. Hum Mol Genet, 2014 Apr 15. PMID 24293545
    3. Deubiquitinase USP47/UBP64E Regulates β-Catenin Ubiquitination and Degradation and Plays a Positive Role in Wnt Signaling. Shi J, et al. Mol Cell Biol, 2015 Oct. PMID 26169834, Free PMC Article
    4. Tribbles in disease: Signaling pathways important for cellular function and neoplastic transformation. Yokoyama T, et al. Cancer Sci, 2011 Jun. PMID 21338441
    5. Proteomic mapping of Drosophila transgenic elav.L-GAL4/+ brain as a tool to illuminate neuropathology mechanisms. Velentzas AD, et al. Sci Rep, 2020 Mar 25. PMID 32214222, Free PMC Article

    See all (78) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In the presence of USP47, MAPK would be stabilized as USP47 acts to deubiquitinate MAPK, thus counteracting the direct ubiquitination of MAPK by POE/UBR4 activity.
      Title: The Deubiquitinase USP47 Stabilizes MAPK by Counteracting the Function of the N-end Rule ligase POE/UBR4 in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in compound eye cone cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in compound eye cone cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of epidermal growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of sevenless signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein stabilization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of protein stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ubiquitin specific protease 47
    Names
    CG5486-PA
    CG5486-PB
    CG5486-PD
    Ubiquitin-specific protease 64E
    Usp47-PA
    Usp47-PB
    Usp47-PD
    NP_523937.2
    NP_729087.1
    NP_996001.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      5752973..5761886
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206279.4 → NP_996001.2  ubiquitin specific protease 47, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996001.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24574
      Conserved Domains (3) summary
      cd02659
      Location:376 → 762
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam07404
      Location:119 → 234
      TEBP_beta; Telomere-binding protein beta subunit (TEBP beta)
      pfam00443
      Location:377 → 758
      UCH; Ubiquitin carboxyl-terminal hydrolase

    2. NM_168129.4 → NP_729087.1  ubiquitin specific protease 47, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729087.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V1I7, Q24574, Q95TM9, Q9VRP1
      Related
      FBpp0076802
      Conserved Domains (4) summary
      cd02659
      Location:394 → 780
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam07404
      Location:119 → 234
      TEBP_beta; Telomere-binding protein beta subunit (TEBP beta)
      pfam00443
      Location:395 → 776
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam05104
      Location:122 → 265
      Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region

    3. NM_079213.4 → NP_523937.2  ubiquitin specific protease 47, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523937.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V1I7, Q24574, Q95TM9, Q9VRP1
      Related
      FBpp0076803
      Conserved Domains (4) summary
      cd02659
      Location:394 → 780
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam07404
      Location:119 → 234
      TEBP_beta; Telomere-binding protein beta subunit (TEBP beta)
      pfam00443
      Location:395 → 776
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam05104
      Location:122 → 265
      Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24574.2 Q24574
    Q95RT0 Q95RT0

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