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    Sk1 Sphingosine kinase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32089, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sk1provided by FlyBase
    Official Full Name
    Sphingosine kinase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0030300
    Locus tag
    Dmel_CG1747
    See related
    AllianceGenome:FB:FBgn0030300
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1747; Dmel\CG1747; sk1; SK1; Sphk1; SphK1
    Summary
    Enables D-erythro-sphingosine kinase activity. Involved in sphingolipid metabolic process. Located in cytosol and plasma membrane. Is expressed in adult head; embryonic/larval midgut primordium; gut section; and mesoderm. Used to study cardiomyopathy. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to several human genes including SPHK2 (sphingosine kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sk1 in Genome Data Viewer
    Location:
    10B13-10B13; 1-34 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11442539..11446012)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11336572..11340045)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Odorant receptor 10a Neighboring gene Gustatory receptor 10a Neighboring gene Glutamine synthetase 2 Neighboring gene Ecotropic viral integration site 5 Neighboring gene Heterochromatin protein 5 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Glial Sphingosine-Mediated Epigenetic Regulation Stabilizes Synaptic Function in Drosophila Models of Alzheimer's Disease. Yin P, et al. J Neurosci, 2023 Oct 18. PMID 37669862, Free PMC Article
    2. Characterization of the Drosophila sphingosine kinases and requirement for Sk2 in normal reproductive function. Herr DR, et al. J Biol Chem, 2004 Mar 26. PMID 14722126
    3. Sphingosine kinases and their metabolites modulate endolysosomal trafficking in photoreceptors. Yonamine I, et al. J Cell Biol, 2011 Feb 21. PMID 21321100, Free PMC Article
    4. Systemic and heart autonomous effects of sphingosine Δ4 desaturase deficiency in lipotoxic cardiac pathophysiology. Walls SM, et al. Dis Model Mech, 2020 Aug 14. PMID 32641420, Free PMC Article
    5. Genetic elevation of sphingosine 1-phosphate suppresses dystrophic muscle phenotypes in Drosophila. Pantoja M, et al. Development, 2013 Jan 1. PMID 23154413, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sk1 and Sk2 are not redundant in biological function and are essential for diverse physiological functions in Drosophila
      Title: Characterization of the Drosophila sphingosine kinases and requirement for Sk2 in normal reproductive function.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables D-erythro-sphingosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables D-erythro-sphingosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in sphingolipid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sphingosine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sphingosine kinase 1
    Names
    CG1747-PA
    CG1747-PB
    Sk1-PA
    Sk1-PB
    sphingosine kinase I
    NP_572717.1
    NP_727528.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      11442539..11446012
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167286.2 → NP_727528.1  sphingosine kinase 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727528.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VYY8
      Related
      FBpp0073346
      Conserved Domains (2) summary
      PLN02958
      Location:189 → 622
      PLN02958; diacylglycerol kinase/D-erythro-sphingosine kinase
      pfam00781
      Location:191 → 330
      DAGK_cat; Diacylglycerol kinase catalytic domain

    2. NM_132489.2 → NP_572717.1  sphingosine kinase 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572717.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VYY8
      Related
      FBpp0073347
      Conserved Domains (2) summary
      PLN02958
      Location:189 → 622
      PLN02958; diacylglycerol kinase/D-erythro-sphingosine kinase
      pfam00781
      Location:191 → 330
      DAGK_cat; Diacylglycerol kinase catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VYY8 Q9VYY8

    Gene LinkOut

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