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    boca boca [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 48986, updated on 9-Dec-2024

    Summary

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    Official Symbol
    bocaprovided by FlyBase
    Official Full Name
    bocaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0004132
    Locus tag
    Dmel_CG30498
    See related
    AllianceGenome:FB:FBgn0004132
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Boca; CG1364; CG30498; dmBoca; Dmel\CG30498; l(2)43Ea
    Summary
    Involved in endoplasmic reticulum to Golgi vesicle-mediated transport; protein folding; and protein targeting to membrane. Located in apical part of cell and endoplasmic reticulum lumen. Is expressed in adult head; adult heart; embryonic/larval salivary gland body; and organism. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 20. Orthologous to human MESD (mesoderm development LRP chaperone). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See boca in Genome Data Viewer
    Location:
    43D7-43D7; 2-56 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7565873..7566738, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3453378..3454243, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Glycerophosphate oxidase 2 Neighboring gene uncharacterized protein Neighboring gene corin Neighboring gene Ribulose-5-phosphate-3-epimerase Neighboring gene Vacuolar protein sorting 13 Neighboring gene antisense RNA:CR45130 Neighboring gene blown fuse

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila reticulon, Rtnl-1, has multiple differentially expressed isoforms that are associated with a sub-compartment of the endoplasmic reticulum. Wakefield S, et al. Cell Mol Life Sci, 2006 Sep. PMID 16847576, Free PMC Article
    2. Structural characterization of the Boca/Mesd maturation factors for LDL-receptor-type β propeller domains. Collins MN, et al. Structure, 2011 Mar 9. PMID 21397184, Free PMC Article
    3. Drosophila KDEL receptor function in the embryonic salivary gland and epidermis. Abrams EW, et al. PLoS One, 2013. PMID 24204897, Free PMC Article
    4. Characterization of the properties of a novel mutation in VAPB in familial amyotrophic lateral sclerosis. Chen HJ, et al. J Biol Chem, 2010 Dec 17. PMID 20940299, Free PMC Article
    5. ER retention of signaling modules. Schlesinger A, et al. Dev Cell, 2005 Feb. PMID 15691755

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Protein interaction data suggest that as LDLRs are translated into the ER, Boca binds to the beta-propeller motif
      Title: Boca-dependent maturation of beta-propeller/EGF modules in low-density lipoprotein receptor proteins.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein folding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting to membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endomembrane system HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum lumen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    boca
    Names
    CG30498-PA
    boca-PA
    lethal(2)43Ea

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7565873..7566738 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165541.2 → NP_724578.1  boca [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724578.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1Z712, Q8T9B6
      Related
      FBpp0088027
      Conserved Domains (1) summary
      pfam10185
      Location:31 → 178
      Mesd; Chaperone for wingless signalling and trafficking of LDL receptor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T9B6.2 Q8T9B6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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