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    SerT Serotonin transporter [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37895, updated on 27-Dec-2024

    Summary

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    Official Symbol
    SerTprovided by FlyBase
    Official Full Name
    Serotonin transporterprovided by FlyBase
    Primary source
    FLYBASE:FBgn0010414
    Locus tag
    Dmel_CG4545
    See related
    AllianceGenome:FB:FBgn0010414
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4545; Dmel\CG4545; dmSERT; DmSerT; DmSERT; dsert; dSert; dSerT; dSERT; dSERT1; serT; Sert; SERT
    Summary
    Enables serotonin:sodium:chloride symporter activity. Involved in serotonin uptake. Located in axon terminus. Is expressed in several structures, including adult brain; anterior-posterior subdivision of organism; ganglia; serotonergic neurons; and synaptic neuropil domain. Used to study depressive disorder and generalized anxiety disorder. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; anxiety disorder (multiple); depressive disorder (multiple); heart disease (multiple); and substance abuse (multiple). Orthologous to human SLC6A4 (solute carrier family 6 member 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See SerT in Genome Data Viewer
    Location:
    60C8-60C8; 2-106 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24404595..24411074, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20292118..20298597, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44813 Neighboring gene Sterile20-like kinase Neighboring gene Regulatory particle non-ATPase 8 Neighboring gene uncharacterized protein Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class Z Neighboring gene prominin Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila serotonin transporters have voltage-dependent uptake coupled to a serotonin-gated ion channel. Galli A, et al. J Neurosci, 1997 May 15. PMID 9133366, Free PMC Article
    2. Sertraline induces DNA damage and cellular toxicity in Drosophila that can be ameliorated by antioxidants. Jajoo A, et al. Sci Rep, 2020 Mar 11. PMID 32161356, Free PMC Article
    3. Interactions of tryptamine derivatives with serotonin transporter species variants implicate transmembrane domain I in substrate recognition. Adkins EM, et al. Mol Pharmacol, 2001 Mar. PMID 11179447
    4. Stereoselective inhibition of serotonin transporters by antimalarial compounds. Beckman ML, et al. Neurochem Int, 2014 Jul. PMID 24161619, Free PMC Article
    5. Structural determinants of species-selective substrate recognition in human and Drosophila serotonin transporters revealed through computational docking studies. Kaufmann KW, et al. Proteins, 2009 Feb 15. PMID 18704946, Free PMC Article

    See all (103) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. show that dSERT mutant animals exhibit an increased survival rate in stress conditions, increased basal motor behavior, and decreased levels in an anxiety-related parameter, centrophobism
      Title: Characterization of a Novel Drosophila SERT Mutant: Insights on the Contribution of the Serotonin Neural System to Behaviors.
    2. Data suggest that functional differences between human, and Drosophila melanogaster, and Caenorhabditis elegans serotonin transporters (SERT) in recognition of MDMA (3,4-methylenedioxy-methamphetamine, "ecstasy") as substrate are due to a single amino acid in transmembrane domain 10 (Glu394 in hSERT; Asn484 in dmSERT; Asp517 in ceSERT).
      Title: The external gate of the human and Drosophila serotonin transporters requires a basic/acidic amino acid pair for 3,4-methylenedioxymethamphetamine (MDMA) translocation and the induction of substrate efflux.
    3. These data suggest that a small number of neurons selectively express factor(s) required for 5-HT storage, and potentially for function of dSERT.
      Title: Cell-type-specific limitation on in vivo serotonin storage following ectopic expression of the Drosophila serotonin transporter, dSERT.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables monoamine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serotonin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serotonin:sodium:chloride symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serotonin:sodium:chloride symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in amino acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoamine transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in serotonin transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in serotonin uptake IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in serotonin uptake IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axon terminus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serotonin transporter
    Names
    CG4545-PA
    CG4545-PB
    CG4545-PC
    SerT-PA
    SerT-PB
    SerT-PC
    cocaine-sensitive serotonin transporter
    drosophila serotonin transporter

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24404595..24411074 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299910.1 → NP_001286839.1  serotonin transporter, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286839.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P51905, Q23969, Q9W177
      UniProtKB/TrEMBL
      A0A0B4LHJ6
      Conserved Domains (1) summary
      cd11497
      Location:74 → 607
      SLC6sbd_SERT-like; Na(+)- and Cl(-)-dependent monoamine transporters, SERT, NET, DAT1 and related proteins; solute binding domain

    2. NM_001382130.1 → NP_001369117.1  serotonin transporter, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6M3Q7U3
      Conserved Domains (1) summary
      cd11497
      Location:74 → 607
      SLC6sbd_SERT-like; Na(+)- and Cl(-)-dependent monoamine transporters, SERT, NET, DAT1 and related proteins; solute binding domain

    3. NM_079122.3 → NP_523846.2  serotonin transporter, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523846.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P51905, Q23969, Q9W177
      UniProtKB/TrEMBL
      A0A0B4LHJ6
      Related
      FBpp0072269
      Conserved Domains (1) summary
      cd11497
      Location:74 → 607
      SLC6sbd_SERT-like; Na(+)- and Cl(-)-dependent monoamine transporters, SERT, NET, DAT1 and related proteins; solute binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LHJ6 A0A0B4LHJ6
    A0A6M3Q7U3 A0A6M3Q7U3
    P51905.1 P51905

    Gene LinkOut

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