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    EB1B end binding protein 1B [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836370, updated on 18-Sep-2024

    Summary

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    Official Symbol
    EB1B
    Official Full Name
    end binding protein 1B
    Primary source
    TAIR:AT5G62500
    Locus tag
    AT5G62500
    See related
    Araport:AT5G62500
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATEB1; ATEB1B; end binding protein 1B; END BINDING PROTEIN 1B; K19B1.11; K19B1_11
    Summary
    encodes a homolog of animal microtubule-end-binding protein. There are two other members of this family. EB1 forms foci at regions where the minus ends of microtubules are gathered during mitosis and early cytokinesis.
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    Genomic context

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    See EB1B in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    8
    Sequence:
    Chromosome: 5; NC_003076.8 (25092641..25095310)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase tau 9 Neighboring gene HVA22 homologue B Neighboring gene F-box family protein Neighboring gene uncharacterized protein Neighboring gene aldehyde dehydrogenase 12A1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The microtubule associated protein END BINDING 1 represses root responses to mechanical cues. Gleeson L, et al. Plant Sci, 2012 May. PMID 22404827
    2. EB1 contributes to microtubule bundling and organization, along with root growth, in Arabidopsis thaliana. Molines AT, et al. Biol Open, 2018 Aug 2. PMID 29945874, Free PMC Article
    3. The microtubule plus-end tracking proteins SPR1 and EB1b interact to maintain polar cell elongation and directional organ growth in Arabidopsis. Galva C, et al. Plant Cell, 2014 Nov. PMID 25415978, Free PMC Article
    4. The microtubule plus-end binding protein EB1 functions in root responses to touch and gravity signals in Arabidopsis. Bisgrove SR, et al. Plant Cell, 2008 Feb. PMID 18281505, Free PMC Article
    5. EB1 reveals mobile microtubule nucleation sites in Arabidopsis. Chan J, et al. Nat Cell Biol, 2003 Nov. PMID 14557818

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SPR1 and EB1b have complex interactions as they load onto microtubule plus ends and direct polar cell expansion and organ growth in response to directional cues.
      Title: The microtubule plus-end tracking proteins SPR1 and EB1b interact to maintain polar cell elongation and directional organ growth in Arabidopsis.
    2. eb1b-1 mutant roots exhibit an increase over wild type in their response to touch... Mutant roots are also hypersensitive to increased levels of mechanical stimulation, revealing the presence of another process that activates the response.
      Title: The microtubule associated protein END BINDING 1 represses root responses to mechanical cues.
    3. The results suggest that a plant-specific EB1 subtype has evolved to function preferentially on the spindle microtubules by accumulating in the prophase nucleus.
      Title: Nuclear-localized subtype of end-binding 1 protein regulates spindle organization in Arabidopsis.
    4. Data find that antibodies directed against EB1 proteins colocalize with microtubules in roots, and that mutants with reduced expression from EB1B genes have roots that deviate toward the left on vertical or inclined plates.
      Title: The microtubule plus-end binding protein EB1 functions in root responses to touch and gravity signals in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_125644.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within microtubule bundle formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive gravitropism IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within thigmotropism IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cortical microtubule, transverse to long axis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in microtubule HDA PubMed 
    located_in microtubule organizing center IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in phragmoplast HDA PubMed 
    located_in spindle HDA PubMed 

    General protein information

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    Preferred Names
    end binding protein 1B
    NP_201056.1
    • end binding protein 1B (EB1B); FUNCTIONS IN: microtubule binding; INVOLVED IN: thigmotropism, cytoskeleton organization, positive gravitropism; LOCATED IN: in 6 components; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Calponin-homology (InterPro:IPR016146), Calponin-like actin-binding (InterPro:IPR001715), EB1, C-terminal (InterPro:IPR004953); BEST Arabidopsis thaliana protein match is: microtubule end binding protein EB1A (TAIR:AT3G47690.1); Has 1005 Blast hits to 968 proteins in 223 species: Archae - 0; Bacteria - 0; Metazoa - 581; Fungi - 144; Plants - 110; Viruses - 3; Other Eukaryotes - 167 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      25092641..25095310
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125644.3 → NP_201056.1  end binding protein 1B [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_201056.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8GYG7, Q9FJJ5
      UniProtKB/TrEMBL
      A0A178UC35, A0A5S9YGK1
      Conserved Domains (2) summary
      pfam00307
      Location:16 → 113
      CH; Calponin homology (CH) domain
      pfam03271
      Location:206 → 243
      EB1; EB1-like C-terminal motif
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FJJ5.1

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