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    DRP3B dynamin related protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 815898, updated on 18-Sep-2024

    Summary

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    Official Symbol
    DRP3B
    Official Full Name
    dynamin related protein
    Primary source
    TAIR:AT2G14120
    Locus tag
    AT2G14120
    See related
    Araport:AT2G14120
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ADL2B; dynamin related protein; T22C12.5; T22C12_5
    Summary
    Encodes a dynamin related protein. DRPs are self-assembling GTPasse involved in fission and fusion of membranes. DRP3B functions in mitochondrion and peroxisome fission in combination with DRP3A.
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    Genomic context

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    See DRP3B in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    21
    Sequence:
    Chromosome: 2; NC_003071.7 (5953940..5960263, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 705, subfamily A, polypeptide 13 Neighboring gene Haloacid dehalogenase-like hydrolase (HAD) superfamily protein Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The mitochondrial fission regulator DRP3B does not regulate cell death in plants. Yoshinaga K, et al. Ann Bot, 2006 Jun. PMID 16533833, Free PMC Article
    2. Phosphorylation and ubiquitination of dynamin-related proteins (AtDRP3A/3B) synergically regulate mitochondrial proliferation during mitosis. Wang F, et al. Plant J, 2012 Oct. PMID 22595081
    3. Differential roles of Arabidopsis dynamin-related proteins DRP3A, DRP3B, and DRP5B in organelle division. Aung K, et al. J Integr Plant Biol, 2012 Nov. PMID 23046048
    4. Arabidopsis dynamin-related proteins DRP3A and DRP3B are functionally redundant in mitochondrial fission, but have distinct roles in peroxisomal fission. Fujimoto M, et al. Plant J, 2009 May. PMID 19144001
    5. Two small protein families, DYNAMIN-RELATED PROTEIN3 and FISSION1, are required for peroxisome fission in Arabidopsis. Zhang X, et al. Plant J, 2009 Jan. PMID 18785999

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Post-translational modifications of DRP3A/3B in BY-2 suspension cells regulate the morphological dynamics of mitochondria during mitosis.
      Title: Phosphorylation and ubiquitination of dynamin-related proteins (AtDRP3A/3B) synergically regulate mitochondrial proliferation during mitosis.
    2. The roles of DRP3A, DRP3B, and DRP5B in organelle division and plant development, were investigated.
      Title: Differential roles of Arabidopsis dynamin-related proteins DRP3A, DRP3B, and DRP5B in organelle division.
    3. DRP3B and DRP3A have redundant molecular functions in mitochondrial fission, whereas DRP3B has a minor role in peroxisomal fission that is distinct from that of DRP3A.
      Title: Arabidopsis dynamin-related proteins DRP3A and DRP3B are functionally redundant in mitochondrial fission, but have distinct roles in peroxisomal fission.
    4. DRP3B is partially targeted to peroxisomes and causes defects in peroxisome fission when the gene function is disrupted.
      Title: Two small protein families, DYNAMIN-RELATED PROTEIN3 and FISSION1, are required for peroxisome fission in Arabidopsis.
    5. Systems controlling cell death in animals and plants are not common in terms of mitochondrial fission.
      Title: The mitochondrial fission regulator DRP3B does not regulate cell death in plants.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001161044.1
    NM_001335415.1
    NM_126984.4
    NM_126985.6

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within mitochondrial fission IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within peroxisome fission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within post-embryonic development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    dynamin related protein
    NP_001154516.1
    • dynamin related protein (DRP3B); FUNCTIONS IN: GTP binding, GTPase activity; INVOLVED IN: post-embryonic development, peroxisome fission, mitochondrial fission; LOCATED IN: mitochondrion, peroxisome; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Dynamin GTPase effector (InterPro:IPR003130), Dynamin, GTPase domain (InterPro:IPR001401), Dynamin, GTPase region, conserved site (InterPro:IPR019762), GTPase effector domain, GED (InterPro:IPR020850), Dynamin central region (InterPro:IPR000375); BEST Arabidopsis thaliana protein match is: dynamin-related protein 3A (TAIR:AT4G33650.1); Has 2998 Blast hits to 2775 proteins in 332 species: Archae - 0; Bacteria - 6; Metazoa - 1280; Fungi - 797; Plants - 522; Viruses - 0; Other Eukaryotes - 393 (source: NCBI BLink).
    NP_565362.1
    • dynamin related protein (DRP3B); FUNCTIONS IN: GTP binding, GTPase activity; INVOLVED IN: post-embryonic development, peroxisome fission, mitochondrial fission; LOCATED IN: mitochondrion, peroxisome, plasma membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Dynamin GTPase effector (InterPro:IPR003130), Dynamin, GTPase region, conserved site (InterPro:IPR019762), GTPase effector domain, GED (InterPro:IPR020850), Dynamin, GTPase domain (InterPro:IPR001401), Dynamin central region (InterPro:IPR000375); BEST Arabidopsis thaliana protein match is: dynamin-related protein 3A (TAIR:AT4G33650.1); Has 3025 Blast hits to 2803 proteins in 339 species: Archae - 2; Bacteria - 6; Metazoa - 1276; Fungi - 842; Plants - 505; Viruses - 0; Other Eukaryotes - 394 (source: NCBI BLink).
    NP_565363.2
    • dynamin related protein (DRP3B); FUNCTIONS IN: GTP binding, GTPase activity; INVOLVED IN: post-embryonic development, peroxisome fission, mitochondrial fission; LOCATED IN: mitochondrion, peroxisome, plasma membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Dynamin GTPase effector (InterPro:IPR003130), Dynamin, GTPase domain (InterPro:IPR001401), Dynamin, GTPase region, conserved site (InterPro:IPR019762), GTPase effector domain, GED (InterPro:IPR020850), Dynamin central region (InterPro:IPR000375); BEST Arabidopsis thaliana protein match is: dynamin-related protein 3A (TAIR:AT4G33650.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      5953940..5960263 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_126985.6 → NP_565363.2  dynamin related protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565363.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9WXY8, A0A7G2EC88, F4IFG1
      Conserved Domains (3) summary
      cd08771
      Location:41 → 315
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      pfam01031
      Location:237 → 523
      Dynamin_M; Dynamin central region
      pfam02212
      Location:653 → 740
      GED; Dynamin GTPase effector domain

    2. NM_001161044.1 → NP_001154516.1  dynamin related protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001154516.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654EUB9, F4IFG2
      Conserved Domains (4) summary
      cd08771
      Location:41 → 315
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      COG0699
      Location:98 → 766
      CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
      pfam01031
      Location:238 → 552
      Dynamin_M; Dynamin central region
      pfam02212
      Location:682 → 769
      GED; Dynamin GTPase effector domain

    3. NM_126984.4 → NP_565362.1  dynamin related protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565362.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LFT2, Q8LPH8, Q8S8A4, Q8S943, Q9SI47
      UniProtKB/TrEMBL
      A0A654EUB9
      Conserved Domains (4) summary
      cd08771
      Location:41 → 315
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      COG0699
      Location:98 → 737
      CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
      pfam01031
      Location:238 → 523
      Dynamin_M; Dynamin central region
      pfam02212
      Location:653 → 740
      GED; Dynamin GTPase effector domain

    4. NM_001335415.1 → NP_001323471.1  dynamin related protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AX46, A0A5S9WXY8, A0A654EUB9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8LFT2.2

    Gene LinkOut

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