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    PUM5 pumilio 5 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821569, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PUM5
    Official Full Name
    pumilio 5
    Primary source
    TAIR:AT3G20250
    Locus tag
    AT3G20250
    See related
    Araport:AT3G20250
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    APUM5; pumilio 5
    Summary
    Encodes a member of the Arabidopsis Pumilio (APUM) proteins containing PUF domain (eight repeats of approximately 36 amino acids each). PUF proteins regulate both mRNA stability and translation through sequence-specific binding to the 3' UTR of target mRNA transcripts.
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    Genomic context

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    See PUM5 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    10
    Sequence:
    Chromosome: 3; NC_003074.8 (7058871..7063372, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene SAUR-like auxin-responsive protein family Neighboring gene Ribosomal L18p/L5e family protein Neighboring gene ncRNA Neighboring gene Mitochondrial substrate carrier family protein Neighboring gene DUF1666 family protein (DUF1666) Neighboring gene lipid-binding serum glycoprotein family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. APUM5, encoding a Pumilio RNA binding protein, negatively regulates abiotic stress responsive gene expression. Huh SU, et al. BMC Plant Biol, 2014 Mar 25. PMID 24666827, Free PMC Article
    2. Role of Arabidopsis Pumilio RNA binding protein 5 in virus infection. Un Huh S, et al. Plant Signal Behav, 2013 May. PMID 23511198, Free PMC Article
    3. Arabidopsis Pumilio protein APUM5 suppresses Cucumber mosaic virus infection via direct binding of viral RNAs. Huh SU, et al. Proc Natl Acad Sci U S A, 2013 Jan 8. PMID 23269841, Free PMC Article
    4. Molecular characterization of Arabidopsis thaliana PUF proteins--binding specificity and target candidates. Francischini CW, et al. FEBS J, 2009 Oct. PMID 19682068
    5. Isolation and identification of ubiquitin-related proteins from Arabidopsis seedlings. Igawa T, et al. J Exp Bot, 2009. PMID 19429840, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. APUM5 may be a new post-transcriptional regulator of the abiotic stress response by direct binding of target genes 3' UTRs.
      Title: APUM5, encoding a Pumilio RNA binding protein, negatively regulates abiotic stress responsive gene expression.
    2. APUM5 acts as a defensive repressor in plants during cucumber mosaic virus infection.
      Title: Role of Arabidopsis Pumilio RNA binding protein 5 in virus infection.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001338465.1
    NM_001338467.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables mRNA binding HDA PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables single-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within 3'-UTR-mediated mRNA destabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within drought recovery IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in plant-type vacuole HDA PubMed 

    General protein information

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    Preferred Names
    pumilio 5
    NP_001319600.1
    • pumilio 5 (PUM5); FUNCTIONS IN: RNA binding, binding; LOCATED IN: vacuole; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Pumilio RNA-binding repeat (InterPro:IPR001313), Armadillo-like helical (InterPro:IPR011989), Armadillo-type fold (InterPro:IPR016024); BEST Arabidopsis thaliana protein match is: pumilio 6 (TAIR:AT4G25880.1); Has 4771 Blast hits to 2450 proteins in 259 species: Archae - 0; Bacteria - 10; Metazoa - 1074; Fungi - 1429; Plants - 1087; Viruses - 0; Other Eukaryotes - 1171 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      7058871..7063372 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001338466.1 → NP_001327305.1  pumilio 5 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WRA5, Q9LJX4
      UniProtKB/TrEMBL
      A0A178VL84, A0A1I9LRW8, A0A384KVB4
      Conserved Domains (2) summary
      cd07920
      Location:611 → 931
      Pumilio; Pumilio-family RNA binding domain
      COG5099
      Location:194 → 935
      COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]

    2. NM_001338465.1 → NP_001319600.1  pumilio 5 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2H1ZEI5, A0A5S9XDW9

    3. NM_001338467.1 → NP_001327304.1  pumilio 5 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WRA5, Q9LJX4
      UniProtKB/TrEMBL
      A0A178VL84, A0A1I9LRW8, A0A384KVB4
      Conserved Domains (2) summary
      cd07920
      Location:611 → 931
      Pumilio; Pumilio-family RNA binding domain
      COG5099
      Location:194 → 935
      COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version

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