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    CDKB1;2 cyclin-dependent kinase B1;2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818444, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CDKB1;2
    Official Full Name
    cyclin-dependent kinase B1;2
    Primary source
    TAIR:AT2G38620
    Locus tag
    AT2G38620
    See related
    Araport:AT2G38620
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    cyclin-dependent kinase B1;2; CYCLIN-DEPENDENT KINASE B1;2; T6A23.18; T6A23_18
    Summary
    Encodes a member of a plant specific family of cyclin dependent kinases.
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    Genomic context

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    See CDKB1;2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    3
    Sequence:
    Chromosome: 2; NC_003071.7 (16152473..16154086)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene HAD superfamily, subfamily IIIB acid phosphatase Neighboring gene RNA-binding KH domain-containing protein Neighboring gene Transducin/WD40 repeat-like superfamily protein Neighboring gene LURP-one-like protein (DUF567) Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CDK-related protein kinases in plants. Joubès J, et al. Plant Mol Biol, 2000 Aug. PMID 11089864
    2. The plant-specific CDKB1-CYCB1 complex mediates homologous recombination repair in Arabidopsis. Weimer AK, et al. EMBO J, 2016 Oct 4. PMID 27497297, Free PMC Article
    3. FOUR LIPS and MYB88 conditionally restrict the G1/S transition during stomatal formation. Lee E, et al. J Exp Bot, 2013 Nov. PMID 24123248, Free PMC Article
    4. Regulation of cell proliferation in the stomatal lineage by the Arabidopsis MYB FOUR LIPS via direct targeting of core cell cycle genes. Xie Z, et al. Plant Cell, 2010 Jul. PMID 20675570, Free PMC Article
    5. Arabidopsis cyclin-dependent kinase C2 interacts with HDA15 and is involved in far-red light-mediated hypocotyl cell elongation. Chen CY, et al. Plant J, 2022 Dec. PMID 36367383

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001036430.3
    NM_001336711.1
    NM_129419.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables RNA polymerase II CTD heptapeptide repeat kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in guard mother cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA endoreduplication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cell cycle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of cell cycle G1/S phase transition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of stomatal complex patterning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of cyclin-dependent protein kinase holoenzyme complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-dependent kinase B1;2
    NP_001031507.1
    • cyclin-dependent kinase B1;2 (CDKB1;2); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase-like domain (InterPro:IPR011009), Protein kinase, catalytic domain (InterPro:IPR000719), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635); BEST Arabidopsis thaliana protein match is: cyclin-dependent kinase B1;1 (TAIR:AT3G54180.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_181396.2
    • cyclin-dependent kinase B1;2 (CDKB1;2); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: cyclin-dependent kinase B1;1 (TAIR:AT3G54180.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      16152473..16154086
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001336710.1 → NP_001324504.1  cyclin-dependent kinase B1;2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2EGI0

    2. NM_001036430.3 → NP_001031507.1  cyclin-dependent kinase B1;2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031507.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q2V419, Q56XK5, Q9ZVI4
      UniProtKB/TrEMBL
      A0A5S9X5B5
      Conserved Domains (2) summary
      PLN00009
      Location:1 → 306
      PLN00009; cyclin-dependent kinase A; Provisional
      cd07837
      Location:2 → 304
      STKc_CdkB_plant; Catalytic domain of the Serine/Threonine Kinase, Plant B-type Cyclin-Dependent protein Kinase

    3. NM_129419.3 → NP_181396.2  cyclin-dependent kinase B1;2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_181396.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2EGI0
      Conserved Domains (1) summary
      cl21453
      Location:2 → 237
      PKc_like; Protein Kinases, catalytic domain

    4. NM_001336711.1 → NP_001324503.1  cyclin-dependent kinase B1;2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B0A0, A0A5S9X5B5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2V419.2

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