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    WOX12 WUSCHEL related homeobox 12 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831649, updated on 18-Sep-2024

    Summary

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    Official Symbol
    WOX12
    Official Full Name
    WUSCHEL related homeobox 12
    Primary source
    TAIR:AT5G17810
    Locus tag
    AT5G17810
    See related
    Araport:AT5G17810
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    MVA3.17; MVA3_17; WUSCHEL related homeobox 12
    Summary
    Encodes a WUSCHEL-related homeobox gene family member with 65 amino acids in its homeodomain. Proteins in this family contain a sequence of eight residues (TLPLFPMH) downstream of the homeodomain called the WUS box.
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    Genomic context

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    See WOX12 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    4
    Sequence:
    Chromosome: 5; NC_003076.8 (5880424..5884770, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene myb domain protein 56 Neighboring gene Peroxidase superfamily protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Time-course transcriptome analysis reveals regulation of Arabidopsis seed dormancy by the transcription factors WOX11/12. Liao J, et al. J Exp Bot, 2023 Feb 5. PMID 36402548
    2. WOX11 and 12 are involved in the first-step cell fate transition during de novo root organogenesis in Arabidopsis. Liu J, et al. Plant Cell, 2014 Mar. PMID 24642937, Free PMC Article
    3. Transcription Factors WOX11/12 Directly Activate WOX5/7 to Promote Root Primordia Initiation and Organogenesis. Hu X, et al. Plant Physiol, 2016 Dec. PMID 27784768, Free PMC Article
    4. Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. Riechmann JL, et al. Science, 2000 Dec 15. PMID 11118137
    5. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Time-course transcriptome analysis reveals regulation of Arabidopsis seed dormancy by the transcription factors WOX11/12.
      Title: Time-course transcriptome analysis reveals regulation of Arabidopsis seed dormancy by the transcription factors WOX11/12.
    2. the expression switch from WOX11/12 to WOX5/7 is critical for initiation of the root primordium during de novo root organogenesis.
      Title: Transcription Factors WOX11/12 Directly Activate WOX5/7 to Promote Root Primordia Initiation and Organogenesis.
    3. WOX11 directly responds to a wounding-induced auxin maximum in and surrounding the procambium and acts redundantly with its homolog WOX12 to upregulate LATERAL ORGAN BOUNDARIES DOMAIN16 (LBD16) and LBD29
      Title: WOX11 and 12 are involved in the first-step cell fate transition during de novo root organogenesis in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001203398.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adventitious root development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within adventitious root development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    WUSCHEL related homeobox 12
    NP_001190327.1
    • WUSCHEL related homeobox 12 (WOX12); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: regulation of transcription, DNA-dependent; CONTAINS InterPro DOMAIN/s: Homeobox (InterPro:IPR001356), Homeodomain-like (InterPro:IPR009057); BEST Arabidopsis thaliana protein match is: WUSCHEL related homeobox 11 (TAIR:AT3G03660.2).
    NP_197283.2
    • WUSCHEL related homeobox 12 (WOX12); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: regulation of transcription, DNA-dependent; CONTAINS InterPro DOMAIN/s: Homeobox (InterPro:IPR001356), Homeodomain-like (InterPro:IPR009057); BEST Arabidopsis thaliana protein match is: WUSCHEL related homeobox 11 (TAIR:AT3G03660.2); Has 533 Blast hits to 523 proteins in 47 species: Archae - 0; Bacteria - 0; Metazoa - 1; Fungi - 0; Plants - 532; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      5880424..5884770 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121787.3 → NP_197283.2  WUSCHEL related homeobox 12 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197283.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8GY25, Q9FN71
      UniProtKB/TrEMBL
      A0A178U995, A0A5S9Y521, A0A7G2FBC0
      Conserved Domains (1) summary
      cl00084
      Location:21 → 72
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    2. NM_001343523.1 → NP_001330983.1  WUSCHEL related homeobox 12 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BCH3, A0A5S9Y521, A0A7G2FBC0

    3. NM_001203398.1 → NP_001190327.1  WUSCHEL related homeobox 12 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190327.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8GY25, Q9FN71
      UniProtKB/TrEMBL
      A0A178U995, A0A5S9Y521, A0A7G2FBC0
      Conserved Domains (1) summary
      cl00084
      Location:21 → 72
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8GY25.1

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