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    Dihydrolipoamide succinyltransferase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828798, updated on 18-Sep-2024

    Summary

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    Official Full Name
    Dihydrolipoamide succinyltransferase
    Primary source
    TAIR:AT4G26910
    Locus tag
    AT4G26910
    See related
    Araport:AT4G26910
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F10M23.250; F10M23_250
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    Genomic context

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    Location:
    chromosome: 4
    Exon count:
    14
    Sequence:
    Chromosome: 4; NC_003075.7 (13519811..13523405, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene mitogen-activated protein kinase kinase kinase 16 Neighboring gene HIS HF Neighboring gene START (StAR-related lipid-transfer) lipid-binding domain-containing protein Neighboring gene myb domain protein 97 Neighboring gene Galactosyltransferase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Downregulation of the E2 Subunit of 2-Oxoglutarate Dehydrogenase Modulates Plant Growth by Impacting Carbon-Nitrogen Metabolism in Arabidopsis thaliana. Condori-Apfata JA, et al. Plant Cell Physiol, 2021 Oct 1. PMID 33693904, Free PMC Article
    2. Heterogeneity of the mitochondrial proteome for photosynthetic and non-photosynthetic Arabidopsis metabolism. Lee CP, et al. Mol Cell Proteomics, 2008 Jul. PMID 18385124
    3. The Extra-Pathway Interactome of the TCA Cycle: Expected and Unexpected Metabolic Interactions. Zhang Y, et al. Plant Physiol, 2018 Jul. PMID 29794018, Free PMC Article
    4. The hydrophobic proteome of mitochondrial membranes from Arabidopsis cell suspensions. Brugière S, et al. Phytochemistry, 2004 Jun. PMID 15276431
    5. Divalent metal ions in plant mitochondria and their role in interactions with proteins and oxidative stress-induced damage to respiratory function. Tan YF, et al. Plant Physiol, 2010 Feb. PMID 20018591, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Downregulation of the E2 Subunit of 2-Oxoglutarate Dehydrogenase Modulates Plant Growth by Impacting Carbon-Nitrogen Metabolism in Arabidopsis thaliana.
      Title: Downregulation of the E2 Subunit of 2-Oxoglutarate Dehydrogenase Modulates Plant Growth by Impacting Carbon-Nitrogen Metabolism in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_118825.3
    NM_179121.3
    NM_179122.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables dihydrolipoyllysine-residue succinyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding HDA PubMed 
    Process Evidence Code Pubs
    involved_in L-lysine catabolic process to acetyl-CoA via saccharopine IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    part_of oxoglutarate dehydrogenase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Dihydrolipoamide succinyltransferase
    NP_567761.1
    • Dihydrolipoamide succinyltransferase; FUNCTIONS IN: zinc ion binding, acyltransferase activity; INVOLVED IN: tricarboxylic acid cycle, metabolic process; LOCATED IN: mitochondrion, membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Dihydrolipoamide succinyltransferase (InterPro:IPR006255), 2-oxo acid dehydrogenase, lipoyl-binding site (InterPro:IPR003016), 2-oxoacid dehydrogenase acyltransferase, catalytic domain (InterPro:IPR001078), Single hybrid motif (InterPro:IPR011053), Biotin/lipoyl attachment (InterPro:IPR000089); BEST Arabidopsis thaliana protein match is: Dihydrolipoamide succinyltransferase (TAIR:AT5G55070.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_849452.1
    • Dihydrolipoamide succinyltransferase; FUNCTIONS IN: zinc ion binding, acyltransferase activity; INVOLVED IN: tricarboxylic acid cycle, metabolic process; LOCATED IN: mitochondrion, membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: 2-oxo acid dehydrogenase, lipoyl-binding site (InterPro:IPR003016), Dihydrolipoamide succinyltransferase (InterPro:IPR006255), 2-oxoacid dehydrogenase acyltransferase, catalytic domain (InterPro:IPR001078), Single hybrid motif (InterPro:IPR011053), Biotin/lipoyl attachment (InterPro:IPR000089); BEST Arabidopsis thaliana protein match is: Dihydrolipoamide succinyltransferase (TAIR:AT5G55070.1); Has 25893 Blast hits to 21481 proteins in 2394 species: Archae - 160; Bacteria - 15396; Metazoa - 785; Fungi - 512; Plants - 432; Viruses - 4; Other Eukaryotes - 8604 (source: NCBI BLink).
    NP_849453.1
    • Dihydrolipoamide succinyltransferase; FUNCTIONS IN: zinc ion binding, acyltransferase activity; INVOLVED IN: tricarboxylic acid cycle, metabolic process; LOCATED IN: mitochondrion, membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: 2-oxo acid dehydrogenase, lipoyl-binding site (InterPro:IPR003016), Dihydrolipoamide succinyltransferase (InterPro:IPR006255), 2-oxoacid dehydrogenase acyltransferase, catalytic domain (InterPro:IPR001078), Single hybrid motif (InterPro:IPR011053), Biotin/lipoyl attachment (InterPro:IPR000089); BEST Arabidopsis thaliana protein match is: Dihydrolipoamide succinyltransferase (TAIR:AT5G55070.1); Has 24826 Blast hits to 20752 proteins in 2368 species: Archae - 154; Bacteria - 14691; Metazoa - 760; Fungi - 487; Plants - 406; Viruses - 4; Other Eukaryotes - 8324 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      13519811..13523405 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_179121.3 → NP_849452.1  Dihydrolipoamide succinyltransferase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849452.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178V2M2, A0A5S9XW61
      Conserved Domains (3) summary
      cd06849
      Location:92 → 165
      lipoyl_domain; Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid ...
      PLN02226
      Location:1 → 463
      PLN02226; 2-oxoglutarate dehydrogenase E2 component
      pfam00198
      Location:250 → 461
      2-oxoacid_dh; 2-oxoacid dehydrogenases acyltransferase (catalytic domain)

    2. NM_118825.3 → NP_567761.1  Dihydrolipoamide succinyltransferase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567761.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q3E9W2, Q8H107, Q8LGI7, Q9SZ31
      UniProtKB/TrEMBL
      A0A178V3X4
      Conserved Domains (3) summary
      cd06849
      Location:93 → 166
      lipoyl_domain; Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid ...
      PLN02226
      Location:1 → 464
      PLN02226; 2-oxoglutarate dehydrogenase E2 component
      pfam00198
      Location:251 → 462
      2-oxoacid_dh; 2-oxoacid dehydrogenases acyltransferase (catalytic domain)

    3. NM_179122.1 → NP_849453.1  Dihydrolipoamide succinyltransferase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849453.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8H107
      Conserved Domains (3) summary
      cd06849
      Location:1 → 67
      lipoyl_domain; Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid ...
      PRK05704
      Location:2 → 365
      PRK05704; dihydrolipoamide succinyltransferase; Validated
      pfam00198
      Location:152 → 363
      2-oxoacid_dh; 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8H107.2

    Gene LinkOut

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