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    PYM partner of Y14-MAGO [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837682, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PYM
    Official Full Name
    partner of Y14-MAGO
    Primary source
    TAIR:AT1G11400
    Locus tag
    AT1G11400
    See related
    Araport:AT1G11400
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    partner of Y14-MAGO; T23J18.7; T23J18_7
    Summary
    The PYM gene encodes a protein capable of interacting with MAGO, and Y14, whose orthologs form part of the exon junction complex in animal cells. In vitro binding assays indicate that PYM can bind to MAGO and Y14 either individually, or when they are together. But, MAGO-Y14-PYM ternary complexes are difficult to detect in vivo in Arabidopsis based on pull-down experiments. However there is some evidence for a weak association in Arabidopsis flowers. PYM appears primarily cytoplasmic, but it also seems to into the nucleus at times. Its nuclear localization signal has not been rigorously defined, but there is evidence for a nuclear export signal between amino acids 171-205 in the C-terminus.
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    Genomic context

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    See PYM in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    8
    Sequence:
    Chromosome: 1; NC_003070.9 (3837694..3841218)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Pectin lyase-like superfamily protein Neighboring gene PLAC8 family protein Neighboring gene Protein kinase superfamily protein Neighboring gene ncRNA Neighboring gene S-locus lectin protein kinase family protein Neighboring gene agenet domain protein (DOMAIN OF UNKNOWN FUNCTION 724 2) Neighboring gene plastid developmental protein DAG Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional interconnections of Arabidopsis exon junction complex proteins and genes at multiple steps of gene expression. Mufarrege EF, et al. J Exp Bot, 2011 Oct. PMID 21676911
    2. Biochemical and cellular characterization of the plant ortholog of PYM, a protein that interacts with the exon junction complex core proteins Mago and Y14. Park NI, et al. Planta, 2007 Feb. PMID 16953428
    3. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Overexpression of Mago and Y14 in plants produces an increase in PYM protein levels.
      Title: Functional interconnections of Arabidopsis exon junction complex proteins and genes at multiple steps of gene expression.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_001035946.2
    NM_001331982.1
    NM_001331983.1
    NM_101013.1
    NM_179308.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in exon-exon junction complex disassembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of gene expression IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    partner of Y14-MAGO
    NP_001031023.1
    • partner of Y14-MAGO (PYM); FUNCTIONS IN: protein binding; INVOLVED IN: biological_process unknown; LOCATED IN: nucleoplasm, nucleolus, cytoplasm; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Exon junction complex, Pym (InterPro:IPR015362); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_563890.1
    • partner of Y14-MAGO (PYM); CONTAINS InterPro DOMAIN/s: Exon junction complex, Pym (InterPro:IPR015362); Has 344 Blast hits to 344 proteins in 136 species: Archae - 0; Bacteria - 3; Metazoa - 157; Fungi - 114; Plants - 46; Viruses - 0; Other Eukaryotes - 24 (source: NCBI BLink).
    NP_849639.1
    • partner of Y14-MAGO (PYM); CONTAINS InterPro DOMAIN/s: Exon junction complex, Pym (InterPro:IPR015362); Has 344 Blast hits to 344 proteins in 136 species: Archae - 0; Bacteria - 3; Metazoa - 157; Fungi - 114; Plants - 46; Viruses - 0; Other Eukaryotes - 24 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      3837694..3841218
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001331981.1 → NP_001322145.1  partner of Y14-MAGO [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LG67, Q9LPZ4
      UniProtKB/TrEMBL
      A0A178W3L1, A0A5S9TW97
      Conserved Domains (1) summary
      pfam09282
      Location:22 → 48
      Mago-bind; Mago binding

    2. NM_179308.4 → NP_849639.1  partner of Y14-MAGO [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849639.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LG67, Q9LPZ4
      UniProtKB/TrEMBL
      A0A178W3L1, A0A5S9TW97
      Conserved Domains (1) summary
      pfam09282
      Location:22 → 48
      Mago-bind; Mago binding

    3. NM_001331983.1 → NP_001322144.1  partner of Y14-MAGO [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LG67, Q9LPZ4
      UniProtKB/TrEMBL
      A0A178W3L1, A0A5S9TW97
      Conserved Domains (1) summary
      pfam09282
      Location:22 → 48
      Mago-bind; Mago binding

    4. NM_001331982.1 → NP_001322146.1  partner of Y14-MAGO [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LG67, Q9LPZ4
      UniProtKB/TrEMBL
      A0A178W3L1, A0A5S9TW97
      Conserved Domains (1) summary
      pfam09282
      Location:22 → 48
      Mago-bind; Mago binding

    5. NM_101013.1 → NP_563890.1  partner of Y14-MAGO [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_563890.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LG67, Q9LPZ4
      UniProtKB/TrEMBL
      A0A178W3L1, A0A5S9TW97
      Conserved Domains (1) summary
      pfam09282
      Location:22 → 48
      Mago-bind; Mago binding

    6. NM_001035946.2 → NP_001031023.1  partner of Y14-MAGO [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031023.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LG67, Q9LPZ4
      UniProtKB/TrEMBL
      A0A178W3L1, A0A5S9TW97
      Conserved Domains (1) summary
      pfam09282
      Location:22 → 48
      Mago-bind; Mago binding
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LPZ4.1

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