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    PEX4 peroxin4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 832645, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PEX4
    Official Full Name
    peroxin4
    Primary source
    TAIR:AT5G25760
    Locus tag
    AT5G25760
    See related
    Araport:AT5G25760
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F18A17.10; F18A17_10; peroxin4; UBC21; ubiquitin-conjugating enzyme 21
    Summary
    mutant displays sucrose-dependent seedling development and reduced lateral root production. PEX4 interacts with PEX22 in a yeast two-hybrid. Necessary for peroxisome biogenesis. The PEX4 and PEX22 pair may be important during the remodeling of peroxisome matrix contents as glyoxysomes transition to leaf peroxisomes.
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    Genomic context

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    See PEX4 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    5
    Sequence:
    Chromosome: 5; NC_003076.8 (8967655..8969369)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene RNA polymerase I-associated factor PAF67 Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ubiquitin-conjugating activity by PEX4 is required for efficient protein transport to peroxisomes in Arabidopsis thaliana. Mano S, et al. J Biol Chem, 2022 Jun. PMID 35595097, Free PMC Article
    2. Reconstitution of the plant ubiquitination cascade in bacteria using a synthetic biology approach. Han Y, et al. Plant J, 2017 Aug. PMID 28509348
    3. Elevated growth temperature decreases levels of the PEX5 peroxisome-targeting signal receptor and ameliorates defects of Arabidopsis mutants with an impaired PEX4 ubiquitin-conjugating enzyme. Kao YT, et al. BMC Plant Biol, 2015 Sep 16. PMID 26377801, Free PMC Article
    4. Identification and functional characterization of Arabidopsis PEROXIN4 and the interacting protein PEROXIN22. Zolman BK, et al. Plant Cell, 2005 Dec. PMID 16272432, Free PMC Article
    5. A dual role for the S-locus receptor kinase in self-incompatibility and pistil development revealed by an Arabidopsis rdr6 mutation. Tantikanjana T, et al. Plant Cell, 2009 Sep. PMID 19767457, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ubiquitin-conjugating activity by PEX4 is required for efficient protein transport to peroxisomes in Arabidopsis thaliana.
      Title: Ubiquitin-conjugating activity by PEX4 is required for efficient protein transport to peroxisomes in Arabidopsis thaliana.
    2. Growth at elevated temperature did not reduce the fraction of membrane-associated PEX5 in pex4-1 mutants, suggesting that elevated temperature did not restore PEX4 enzymatic function in the mutant.
      Title: Elevated growth temperature decreases levels of the PEX5 peroxisome-targeting signal receptor and ameliorates defects of Arabidopsis mutants with an impaired PEX4 ubiquitin-conjugating enzyme.
    3. PEX4 is necessary for Arabidopsis peroxisomal function. pex4 mutants are sucrose dependent during germination and display reduced responses to the auxin precursor indole-3-butyric acid, presumably due to peroxisomal beta-oxidation defects.
      Title: Identification and functional characterization of Arabidopsis PEROXIN4 and the interacting protein PEROXIN22.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001036862.2
    NM_122477.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin conjugating enzyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within fatty acid beta-oxidation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within peroxisome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein import into peroxisome matrix IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    peroxin4
    NP_001031939.1
    • peroxin4 (PEX4); CONTAINS InterPro DOMAIN/s: Ubiquitin-conjugating enzyme/RWD-like (InterPro:IPR016135), Ubiquitin-conjugating enzyme, E2 (InterPro:IPR000608); BEST Arabidopsis thaliana protein match is: ubiquitin-conjugating enzyme 29 (TAIR:AT2G16740.1); Has 10357 Blast hits to 10353 proteins in 397 species: Archae - 0; Bacteria - 2; Metazoa - 4640; Fungi - 2157; Plants - 1900; Viruses - 24; Other Eukaryotes - 1634 (source: NCBI BLink).
    NP_568476.1
    • peroxin4 (PEX4); CONTAINS InterPro DOMAIN/s: Ubiquitin-conjugating enzyme/RWD-like (InterPro:IPR016135), Ubiquitin-conjugating enzyme, E2 (InterPro:IPR000608); BEST Arabidopsis thaliana protein match is: ubiquitin-conjugating enzyme 29 (TAIR:AT2G16740.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      8967655..8969369
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_122477.2 → NP_568476.1  peroxin4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568476.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LGF7
      UniProtKB/TrEMBL
      A0A5S9Y8C9, A0A654G461
      Conserved Domains (1) summary
      pfam00179
      Location:7 → 148
      UQ_con; Ubiquitin-conjugating enzyme

    2. NM_001036862.2 → NP_001031939.1  peroxin4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031939.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LGF7
      UniProtKB/TrEMBL
      A0A5S9Y8C9, A0A654G461
      Conserved Domains (1) summary
      pfam00179
      Location:7 → 148
      UQ_con; Ubiquitin-conjugating enzyme
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8LGF7.1

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